In this study, we also examined the effect of picolinic acid on the growth of epimastigote forms and the motility of trypomastigote forms of M5-2 strain of Schizotrypanum trypanosomes isolated from bat Phyllostomus hastatus.
The 50% cytotoxic concentration of picolinic acid after 4 days incubation ([CC.
The mechanisms of action of picolinic acid regarding the inhibitory effects on M5-2 trypanosomes are unclear.
On the other hand, picolinic acid is a structural analogue of nicotinic acid (3-pyridinecarboxylic acid) and nicotinamide which are supplied in chemically defined medium for trypanosomatid growth (MELO et al.
The effects of picolinic acid are partially reversed by nicotinic acid (Figure 2A, p < 0.
Augmented inhibition of Candida albicans growth by murine neutrophils in the presence of a tryptophan metabolite, picolinic acid.
Macrophage activating properties of the tryptophan catabolite picolinic acid.
Antimicrobial activity of picolinic acid against extracellular and intracellular Mycobacterium avium complex and its combined activity with clarithromycin, rifampicin and fluoroquinolones.
Antiviral, cytotoxic and apoptotic activities of picolinic acid on human immunodeficiency virus-1 and human herpes simplex virus-2 infected cells.
Antitumor activity of picolinic acid in CBA/J mice.
Antifungal activity of macrophages engineered to produce IFN[gamma]: inducibility by picolinic acid.