pilocarpine


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pilocarpine

(pīlōkär`pēn), naturally occurring alkaloid obtained from plants of the genus Pilocarpus (family Rutaceae). By mimicking the effects of acetylcholineacetylcholine
, a small organic molecule liberated at nerve endings as a neurotransmitter. It is particularly important in the stimulation of muscle tissue. The transmission of an impulse to the end of the nerve causes it to release neurotransmitter molecules onto the surface of
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, pilocarpine acts as a stimulant of the parasympathetic nervous systemnervous system,
network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment. Virtually all members of the animal kingdom have at least a rudimentary nervous system.
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. It promotes the flow of saliva and urine and increases perspiration. Because it increases the outflow of fluid from the eye, reduces the pressure within the eye, and causes the pupil to contract, the drug is used to treat some types of glaucoma. It is also used for some tongue disorders.

Pilocarpine

 

a cholinomimetic medicine. Pilocarpine is an alkaloid that is obtained from the plant Pilocarpus pinnatifolius, which grows mainly in Brazil. Supplied as the hydrochloride salt, it is used as an ointment or in droplet form for the treatment of certain eye diseases, including glaucoma.

pilocarpine

[‚pī·lə′kär‚pēn]
(organic chemistry)
C11H16N2O2 An alkaloid, in either oil or crystal form, melting at 34°C; soluble in chloroform, water, and alcohol; used in medicine.
References in periodicals archive ?
Stimulated in this manner, pilocarpine produces sweating in a localized area corresponding in size to the positive electrode.
125% pilocarpine drops causes the otherwise slow-to-constrict pupil to constrict intensely, is considered diagnostically additive.
Pilocarpine (300mg/kg ip), preceded by methylscopolamine (l mg/kg, sc) and pentylenetetrazol (PTZ, 50 mg/kg ip) were used to induce seizures as described previously (Lian et al.
Systemic administration of pilocarpine can cause side effects due to parasympathetic intoxication such as sialorrhea, vomiting, diarrhea and bradycardia (GRAHN & STOREY, 2004).
Pilocarpine (Salagen) and cevimeline (Evoxac) tablets may be use to increase salivary flow.
Keywords: hypoglycemia, sweat rate, pilocarpine, hyperhydrosis
Prescription of pilocarpine at a dose and schedule of 5 mg three times daily (up to 30 mg total daily dose) beginning one hour prior to the first radiation dose and continuing potentially life-long.
Several options have been explored, including the use of substances that inhibit catecholamine uptake and metabolism [37] and the use of cholinergic preparations such as pilocarpine.
Pilocarpine acts at parasympathetic muscarinic receptor site to cause ciliary muscle spasm and pupillary miosis.
A drug called pilocarpine hydrochloride has been shown to be safe and effective in relieving dry mouth, often associated with Sjogren's syndrome.
Pilocarpine is an approved generic drug prescribed to both patient groups.
Overproduction of saliva is uncommon, but when present, it is sometimes related to: prescription medications Pilocarpine (for glaucoma) and lithium (to stabilize mood); exposure to heavy metals such as iron, lead, arsenic, and mercury; and organophosphorus (acetylcholinesterase) poisoning.