pilocarpine


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pilocarpine

(pīlōkär`pēn), naturally occurring alkaloid obtained from plants of the genus Pilocarpus (family Rutaceae). By mimicking the effects of acetylcholineacetylcholine
, a small organic molecule liberated at nerve endings as a neurotransmitter. It is particularly important in the stimulation of muscle tissue. The transmission of an impulse to the end of the nerve causes it to release neurotransmitter molecules onto the surface of
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, pilocarpine acts as a stimulant of the parasympathetic nervous systemnervous system,
network of specialized tissue that controls actions and reactions of the body and its adjustment to the environment. Virtually all members of the animal kingdom have at least a rudimentary nervous system.
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. It promotes the flow of saliva and urine and increases perspiration. Because it increases the outflow of fluid from the eye, reduces the pressure within the eye, and causes the pupil to contract, the drug is used to treat some types of glaucoma. It is also used for some tongue disorders.

Pilocarpine

 

a cholinomimetic medicine. Pilocarpine is an alkaloid that is obtained from the plant Pilocarpus pinnatifolius, which grows mainly in Brazil. Supplied as the hydrochloride salt, it is used as an ointment or in droplet form for the treatment of certain eye diseases, including glaucoma.

pilocarpine

[‚pī·lə′kär‚pēn]
(organic chemistry)
C11H16N2O2 An alkaloid, in either oil or crystal form, melting at 34°C; soluble in chloroform, water, and alcohol; used in medicine.
References in periodicals archive ?
Pilocarpine (300mg/kg ip), preceded by methylscopolamine (l mg/kg, sc) and pentylenetetrazol (PTZ, 50 mg/kg ip) were used to induce seizures as described previously (Lian et al.
Peripheral sweat rate was determined using pilocarpine iontophoresis on the flexor surface of both arms and the two values were averaged.
Prescription of pilocarpine at a dose and schedule of 5 mg three times daily (up to 30 mg total daily dose) beginning one hour prior to the first radiation dose and continuing potentially life-long.
Several options have been explored, including the use of substances that inhibit catecholamine uptake and metabolism [37] and the use of cholinergic preparations such as pilocarpine.
TM)]) and THVD-202 are novel, patent-protected therapeutics that combine the muscarinic antagonist tolterodine with modified-release formulations of the muscarinic agonist (salivary stimulant) pilocarpine.
TM)](2mg tolterodine plus 9mg pilocarpine, administered BID) experienced statistically significant improvements in their OAB and UUI symptoms over placebo, with a reduction in daily micturitions of 0.
TM)](2mg tolterodine plus 9mg pilocarpine, administered BID) experienced statistically significant improvements in their OAB and UUI symptoms over placebo control, as well as efficacy similar in magnitude to the maximum dose of active control Detrol[sup.
the United States manufacturing and marketing division of the international generic pharmaceutical company Actavis Group (ICEX: ACT), announced today that it has begun shipping Pilocarpine Hydrochloride 7.
This document describes in detail the quantitative pilocarpine iontophoresis test for the determination of sweat chloride, including techniques to minimize the potential for false-positive and false-negative test results.
in January 2005, the company launched pilocarpine 5mg tablets, the generic version of MGI PHARMA's product, Salagen(R) 5mg Tablets.
Food and Drug Administration (FDA) of its supplemental Abbreviated New Drug Application (ANDAs) for Pilocarpine HCI tablets, 7.
Pilocarpine, a drug that stimulates the salivary glands, improved flow of saliva when used during radiation therapy for head and neck cancer, a Radiation Therapy Oncology Group (RTOG) study reports.