This process is accentuated by intra-plaque hemorrhage and plaque rupture
with resultant thrombus formation.
If other aspects of vulnerable blood are present, such as high platelet reactivity, high blood viscosity, or others, there may be sufficient dysfunction present to result in acute thrombosis even without acute plaque rupture
A biomarker of plaque rupture
would show an increasing concentration when a (coronary) atherosclerotic plaque ruptures
In our case, probably, he has had early onset coronary heart disease in whom the cigarette smoking was the single risk factor and cannabis smoking triggered the plaque rupture
and induced thrombosis.
Some studies have shown that even in the nonallergic setting, mast cells are found in considerably higher amounts at acute plaque rupture
sites than in stable organized thrombus or nonatherosclerotic coronary walls (9, 10).
Among the topics are plaque rupture
models in mice, detecting and quantifying apoptosis in the vasculature, evaluating endothelial function in in-vivo microscopy, assessing protein glocoxidation in ventricular tissues, and stem cell therapy in the heart and vasculature.
Dr Cressida Lyon, from the Bristol Heart Institute, said: "This study is the first demonstration that reduction of cell death with soluble N-cadherin can reduce the likelihood of plaque rupture
Similarly, acute, debilitating stroke, also caused in many cases by plaque rupture
, often occurs without warning.
It is believed that patients with inflammatory disease, including SLE, are more likely to have vulnerable plaque rupture
, accounting for more frequent events.
Plaques containing large lipid cores have been associated with plaque rupture
and thrombosis in patients with coronary artery disease.
4,5) These cholesterol-independent effects include impedance or reversal of atherosclerotic plaque formation, improvements in arterial function, anti-clotting effects, anti-inflammatory effects, antioxidant effects, inhibition of smooth muscle cell proliferation during plaque formation, prevention of plaque rupture
, and prevention of cardiac hypertrophy.
The leading cause of myocardial infarction in patients with coronary artery disease is plaque rupture