occurs when unstable arterial plaque breaks through the smooth arterial wall, triggering the release of white blood cells and other substances to the site.
9) Pre-existing mast-cells within the coronary arteries release proteases upon activation during an anaphylactic event, leading to degradation of extracellular matrix around a plaque site, ultimately contributing to plaque rupture
Pro-inflammatory inducible cyclooxygenase-2/mPGES-1 are overexpressed in symptomatic plaques in association with PGE2-dependent MMP biosynthesis and release leading to plaque rupture
Together, they have been shown to boost stability of deadly soft plaque to help prevent a plaque rupture
, while also slowing and even regressing the accumulation of soft and hard arterial plaque.
The development of a plaque-rupture specific biomarker to aid in the distinction of myocardial injury due to plaque rupture
(T1MI) vs myocardial injury from other pathologies would represent a unique clinical breakthrough (10).
That is, defective fiber assembly or degradation can cause plaque rupture
and subsequent thrombosis, whereas an excessive collagen production can promote plaque growth and thereby contributes to vascular stenosis .
The results indicated C-G transformation enhanced the activity of gene transcription, participated in ECM degradation, invasion of inflammatory cells and plaque rupture
during atherosclerosis, and finally facilitated the onset of CAD and other acute vascular events.
Instead, the amount of coronary atherosclerosis, together with the number of risk factors that encourage plaque rupture
, are better predictors of heart attack, they say.
Angiogenesis is crucial in cancer progression as well as in the development of atherosclerotic plaques and plaque rupture
which can cause heart attacks and stroke.
Her MI was unavoidable since most infarctions are due to plaque rupture
in coronary vessels that aren't occluded enough to require treatment.
With new angina, we assume it could be a heart attack and is the result of a plaque rupture
At present, no test exists that could accurately predict the risk of heart attack since all of the tests currently available for CAD detect the underlying high risk conditions, rather than an impending arterial plaque rupture