Plasma Cell

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plasma cell

[′plaz·mə ‚sel]

Plasma Cell


a type of cell of the connective and hematopoietic tissues. Plasma cells are formed in vertebrates and man from hematopoietic stem cells of the bone marrow. Their principal function is the production of antibodies. Plasma cells are found in lymphatic and hematopoietic tissues, in serous membranes, and in the connective tissues of the organs of digestion and respiration; they accumulate during immunological reactions, for example, to foreign tissues and infection. They are round and have an eccentric nucleus that contains dense clumps of chromatin. The cytoplasm contains large amounts of ribonucleic acid and therefore stains strongly with basic stains. The only region of a plasma cell that absorbs little stain is near the nucleus, where the Golgi complex and the centrosome are located. The plasma cell also exhibits a well-developed endoplasmic reticulum and an abundance of ribosomes, which are characteristic of cells that actively synthesize and secrete proteins.


References in periodicals archive ?
While they exist in small populations in humans, the large amounts of antibodies secreted by plasma cells make them key to the body's immune system and its ability to defend itself against pathogens, such as bacteria and viruses.
Atypical expression of CD20 has been reported in plasma cell neoplasms as well as in a normal, albeit small, subset of T cells.
The fact that plasma cell endometritis persisted in 40% of these women following antibiotic therapy with no identifiable variables that predicted failure raises questions about the importance of identifying plasma cells in the endometrium," Dr.
Sixteen of 21 lymph nodes exhibited at least focal RDD involvement, with numerous histiocytes engulfing lymphocytes, plasma cells, and occasionally neutrophils in their cytoplasm.
The absence of CD 56 (NCAM) on malignant plasma cells is a hallmark of plasma cell leukemia and of a special subset of multiple myeloma.
Pulmonary plasma cell granuloma (inflammatory pseudotumor) with invasion of thoracic vertebra.
The plasma cell level in this patient declined from 95% to 90%.
Our results show that plasma cell enrichment methods greatly increase the sensitivity of FISH for detecting cytogenomic abnormalities in patients with PCNs, particularly in the posttherapy setting, and have clinical relevance.
Abstract: Plasma cell granuloma of the thyroid is a rare tumor-like lesion formed by a localized proliferation of inflammatory cells, supported by a stroma of fibrous tissue.
We present an unusual case of a patient presenting with both monocytic leukemia and plasma cell dyscrasia.
Plasma cell myeloma (PCM) (or multiple myeloma) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are both common hematologic neoplasms, each constituting about 10% to 11% of all hematologic malignancies.