Plasma cell myeloma and CLL are the 2 most common B-cell malignancies occurring in the older adult population.
Notably, none of the patients in this study, in whom clonal B cells were incidentally detected in the marrow, showed plasma cell myeloma in that or subsequent marrow.
Notably, these survival rates are shorter than the 36- to 48-month survival seen in de novo plasma cell myeloma.
The differential diagnosis includes mantle cell lymphoma, CLL/SLL, MZL, and plasma cell myeloma.
Plasma cell myeloma expressing IgM is extremely rare.
18) Notch1 signaling also appears to play a mechanistic role in the human herpesvirus 8 (HHV-8)-mediated and Jagged1-mediated oncogenesis of PEL and plasma cell myeloma, respectively.
For comparison, 5 cases of PEL and 21 cases of plasma cell myeloma were also analyzed.
A diagnosis of plasma cell myeloma was made, and the patient was treated with multiple cycles of chemotherapy.
We present a case of a previously described, but rare, morphologic variant of multiple myeloma known as plasma cell myeloma with multilobated nuclei.