platelet-activating factor


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Related to platelet-activating factor: platelet-activating factor (PAF)

platelet-activating factor

[¦plāt·lət ′ak·tə‚vād·iŋ ‚fak·tər]
(immunology)
A phospholipid released by leukocytes that causes aggregation of platelets and other effects, such as an increase in vascular permeability and bronchoconstriction. Abbreviated PAF.
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References in periodicals archive ?
Recently, a number of studies have examined the association between aspirin resistance and several receptors on the surface of platelets, [sup][21] such as genetic polymorphisms of platelet membrane glycoproteins, genetic mutations of TBXA2R, the platelet-activating factor acetylhydrolase, and coagulation factor XIII.
One of the proposed mechanisms by which GBE could cause bleeding is via the action of ginkgolide B, a constituent of GBE that is reported to be a platelet-activating factor (PAF) antagonist (Smith et al.
regulation of gene expression and maintenance of neural membrane integrity, and serve as precursors for the synthesis of proinflammatory mediators such as eicosanoids (prostaglandins and leukotrienes) and platelet-activating factor (2).
Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.
In addition, proteins involved in regulating HDL function, apolipoprotein A-I (apoA-I), paraoxonase 1 and 3, and platelet-activating factor acetylhydrolase were measured.
Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent nitric-oxide synthase activation.
This results in the release of cytokines with vasoactive and procoagulant properties (interleukins, tumor necrosis factor, platelet-activating factor, and urokinase) (17,18).
Circulating levels of oxidized LDL cholesterol were increased in both lupus groups, as was platelet-activating factor acetylhydrolase (PAF-AH).
These include major basic protein, eosinophilic cationic protein, eosinophil peroxidase, platelet-activating factor, and CLC protein.

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