platelet-activating factor


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Related to platelet-activating factor: platelet-activating factor (PAF)

platelet-activating factor

[¦plāt·lət ′ak·tə‚vād·iŋ ‚fak·tər]
(immunology)
A phospholipid released by leukocytes that causes aggregation of platelets and other effects, such as an increase in vascular permeability and bronchoconstriction. Abbreviated PAF.
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TABLE 91 WORLDWIDE MARKET FOR PLATELET-ACTIVATING FACTOR RECEPTOR ANTAGONISTS, THROUGH 2015 ($ MILLIONS) 137
Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A(2)).
The contractile action of platelet-activating factor on gallbladder smooth muscle.
Platelet-activating factor acetylhydrolase gene polymorphism was analysed in 115 unrelated Turkish patients with a diagnosis of premature CAD who were admitted to the Cardiology Department of the three centers in the Eagean region, West of Turkey.
Although the researchers do not yet have data on platelet-activating factor in humans, they believe blocking it might be effective in the treatment of certain forms of acute and chronic pain.
ta(2,4)-dienoyl-CoA isomerase, mitochondrial, platelet-activating factor acetylhydrolase IB subunit beta, endoplasmic reticulum protein ERP29 (ERP29), protea-some subunit beta type-6, fructose-bisphosphate aldolase A, triosephosphate isomerase (TIM), and D-3-phosphoglycerate dehydrogenase (3-PGDH), while down-regulated proteins are TAR DNA-binding protein 43 (TDP-43), splicing factor, arginine/serinerich 1 (SF2/ASF), cDNA FLJ55253 highly similar to actin cytoplasmic 1, eukaryotic translation initiation factor 3 subunit I (eIF3i), and actin aortic smooth muscle.
That protein is called the platelet-activating factor receptor or PAFr.
Rupatadine is a dual antagonist of histamine and platelet-activating factor (PAF) that has shown promising results in a clinical trial.
These cytokines include platelet-derived growth factor, transforming growth factor B1, platelet-derived epidermal growth factor, platelet-derived angiogenesis factor platelet factor 4, and platelet-activating factor.

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