platelet-derived growth factor


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platelet-derived growth factor

[¦plāt·lət də‚rīvd ′grōth ‚fak·tər]
(cell and molecular biology)
A glycolytic protein released by platelets and other cells that stimulates growth of cells of mesenchymal origin, for example, bone cartilage, vascular tissue, and connective tissue.
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Platelet-derived growth factor receptor [alpha] may provide prognostic value when considered in combination with other factors for the prediction of overall survival in patients diagnosed with RCC.
Increased ET-1 concentrations in combination with platelet-derived growth factors promote vascular smooth muscle proliferation in the neointima of atherosclerotic lesions (52).
Apart from afatinib, Boehringer Ingelheim's late-stage oncology portfolio includes BIBF 1120, an investigational orally-administered triple angiokinase inhibitor that targets three of the receptor tyrosine kinases shown to aid in the regulation of angiogenesis (formation of blood vessels): fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and vascular endothelial growth factor receptor (VEGFR).
Platelet-derived growth factor receptor--a mutations may play a role in other tumors because the kinase is widely expressed in human tissues.
01% Becaplermin) is a recombinant human platelet-derived growth factor (rhPDGF) and was the first biotechnology product approved for the treatment of lower extremity diabetic neuropathic ulcers that extend into the subcutaneous tissue or beyond, and have adequate blood supply, when used as an adjunct to, and not a substitute for, good ulcer care practices including initial sharp debridement, pressure relief and infection control.
XV-615 is novel tyrosine kinase inhibitor with dual activity against the vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR).
All products developed by BioMimetic are based upon recombinant human platelet-derived growth factor (rhPDGF-BB) platform technology, which is a synthetic form of PDGF, one of the body's principal agents to stimulate and direct healing and regeneration.
13 /PRNewswire-FirstCall/ -- Cardium Therapeutics (NYSE Amex: CXM) today reported on new preclinical research findings that Excellagen, a topically applied formulated collagen wound management gel product candidate, activates platelet release of platelet-derived growth factor (PDGF) locally at the wound site.
The device's platelet-derived growth factor is touted by BioMimetic Therapeutics for having five times the rate of chemotaxis (the ability to recruit stem cells) and the ability to stimulate the replication of osteoblasts, not normally typical of bone morphogenetic proteins.
Significant pre-clinical research has been conducted and published by researchers and collaborators at Cardium's Tissue Repair Company and the University of Michigan demonstrating the safety and benefits of adenovector-mediated platelet-derived growth factor gene expression in the areas of periodontal tissue engineering and bone-grafting applications.
today announces revised labeling for REGRANEX Gel, a topical formulation of recombinant human platelet-derived growth factor indicated as an adjunct to the treatment of lower extremity diabetic neuropathic ulcers.

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