platelet-derived growth factor


Also found in: Dictionary, Thesaurus, Medical, Legal, Financial, Acronyms, Wikipedia.

platelet-derived growth factor

[¦plāt·lət də‚rīvd ′grōth ‚fak·tər]
(cell and molecular biology)
A glycolytic protein released by platelets and other cells that stimulates growth of cells of mesenchymal origin, for example, bone cartilage, vascular tissue, and connective tissue.
Mentioned in ?
References in periodicals archive ?
Imatinib mesylate inhibits platelet-derived growth factor receptor phosphorylation of melanoma cells but does not affect tumorigenicity in vivo.
We used the aptamer 41t, which is capable of binding with high affinity to the [beta] chain of the platelet-derived growth factor protein (22), as a negative control; it did not inhibit VEGF-A detection (Fig.
Several growth factors are then released into the tissue from the platelets and from the adjacent cells after injury, including platelet-derived growth factor (PDGF), transforming growth factor-alpha, transforming growth factor-beta (TGF-b) and insulin-like growth factor I (IGF-I) (Antoniades et al.
The expression of CD44, cyclooxygenase 2, and platelet-derived growth factor receptor [alpha] (PDGFR-[alpha]) was evaluated as a potential prognostic factor for survival in patients with RCC.
In addition, other hypoxia-inducible genes, including BCL-2 binding protein Nip3, EGLN1, hypoxia-inducible gene 1 (HIG1), prolyl-4 hydroxylase, and cyclin G2, and growth factors, such as platelet-derived growth factor BB and vascular endothelial growth factor (VEGF), are up-regulated by Ni(II) in an HIF-dependent manner (Kuwabara et al.
decreased platelet-derived growth factor (PDGF); decreased basic fibroblast growth factor (b-FGF); increased keratan sulfate; increased stromelysin; increased ratio of stromelysin to tissue inhibitor of metalloproteases (TIMP); increased osteocalcin; increased alkaline phosphatase; increased cAMP responsive to hormone challenge; increased urokinase plasminogen activator; increased cartilage oligomeric matrix protein; and increased collagenase.
It is a topical gel that contains a genetically engineered, platelet-derived growth factor.
The final AGF concentrate contains important growth factors including Transforming Growth Factor beta (TGF-(beta)) and Platelet-Derived Growth Factor (PDGF).
Platelet-derived growth factor (PDGF) is one of the secretions that bind to a receptor on the surface of some cells in arterial plaque.
and will evaluate the safety and therapeutic potential of escalating doses of a one-time injection of pure recombinant human platelet-derived growth factor (rhPDGF-BB) homodimer solution into the extensor carpi radialis brevis (ECRB), the tendon in the elbow that is generally the source of pain in tennis elbow.

Full browser ?