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In addition, macrophage-derived cytokines, platelet-derived growth factors such as platelet-derived growth factor and transforming growth factor-[beta]1, and lipid pools stimulate the proliferation and migration of adjacent smooth muscle cells, forming the intimal layer of atherosclerotic lesions.
Although hip implants are the largest market segment overall in terms of sales, the highest growth rate over the next few years in Europe is expected in advanced bone morphogenetic proteins (BMPs) and other orthobiologic agents such as allogenic-derived growth factors, blood-extracted growth factors, fibroblast growth factor, gene therapy, recombinant platelet-derived growth factors, small molecule therapies, and stem cells.
Growth factors like platelet-derived growth factor (PDGF) and stem cell factor (SCF) are naturally occurring substances capable of stimulating cellular growth, proliferation and differentiation.

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