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Plethysmography

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Plethysmography 

in medicine and physiology, a method of continuous graphic recording of variations in the volume of a human or animal organ as modified by the circulation of blood. Plethysmography is used to study cardiovascular function and changes in the distribution of blood caused by physical and mental work, fatigue, and emotional responses; it is also used to determine the effects of heat, cold, and tactile and other stimuli and of hypotensive and hypertensive agents. Plethysmography is used in clinical analysis to evaluate vascular tonus and elasticity, pulse volume, and central nervous system function and to investigate corticovisceral functioning by registering the reaction of blood vessels to stimuli.

Figure 1. Plethysmograph: (1) cylindrical container, (2) rubber cuff, (3) tube connecting bottle to container, (4) tube connecting container to Marey capsule, (5) bottle for water, (6) kymograph

The main part of a very simple plethysmograph (Figure 1) is a container of suitable size and shape in which the part, for example, hand, leg, or finger, is placed. In animal experiments a kidney, heart, or spleen may be studied. The container is filled with water and hermetically sealed. (In Figure 1 a rubber cuff is used.) Changes in the water level in the container reflect fluctuations in blood volume in the organ or part and are recorded in the form of a curve called a plethysmogram. The plethysmogram shows small fluctuations in blood pressure corresponding to pulse and somewhat larger ones corresponding to respiration; large variations reflect vascular reactions to various stimuli. More advanced methods of plethysmography include (1) photoplethysmography, in which light is directed through an organ, such as an ear or finger, onto a photoelectric cell, or light is reflected from the organ, (2) rheoplethysmography, and (3) dielectrography, or rheocardiography. The last two methods are based on the direct recording of fluctuations in the electrical properties of an organ, which reflect the dynamics of the organ’s blood supply.

O. M. BENIUMOV



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To assess vascular function in response to ingestion of NOP-47 among 20 healthy men and women, researchers used ultrasound to measure brachial artery dilation in the arm and plethysmography to assess capillary blood flow in the forearm.
The NPSG included the following measurements: * Chest and abdominal wall movement by respiratory impedance or inductance plethysmography * Heart rate by ECG * Airflow with sidestream end-tidal carbon dioxide levels * Pulse oximetric saturation (SpO2) and waveform bilateral electrooculogram * Eight-channel EEG * Chin and anterior tibial EMG * Body position All measurements were digitized and tracheal sound was monitored with a microphone sensor.
 
 
 
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