Such a change would address about half the 32,000 known point mutations
that cause disease.
Inverse mutation and single point mutation
are applied to generate improved chromosomes for obtaining the best objective value.
Six specimens had an ompA genotype identical to the L2 reference strain L2/434/Bu, and 7 had a novel genotype that differed from the L1 reference strain L1/440 by 9 point mutations
RFLP assay was used in the present study as it is a simple, rapid and cost-effective technique for detecting point mutation
at codons 55 and 57 in the DHPS gene of P.
Based on an idea by Joshua Plotkin, a junior fellow in the Faculty of Arts and Sciences at Harvard, the researchers focused on the susceptibility of codons (nucleotide triplets constituting the genetic code) to point mutations
(modification of a single DNA nucleotide) and the fact that not all point mutations
produce the same results.
But a mismatch of one nucleotide, at the point mutation
linked to the disease, activated the cellular DNA repair enzymes to fix the defective gene.
Detection of a novel point mutation
of the prothrombin gene at position 20209.
7 PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON B, Hughes and Federica Verra, a parasitologist and Coluzzi's colleague in Rome, found a large number of point mutations
in 23 locations in the P.
For each DNA sample from a patient, the two PCR reactions for each point mutation
locus were run in two separate lanes on the gel (Fig.
When the mutated gene was translated into a protein, the point mutation
led to the substitution of methionine for lysine as the 27th amino acid in this variant of histone H3 protein.
One such reassortment event (shift), rather than a point mutation
(drift), appears to explain the emergence of the A/Fujian/411/2002-like strain that caused an epidemic during the 2003 2004 influenza season.