point mutation


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Related to point mutation: Insertion mutation, Deletion mutation

point mutation

[′pȯint myü′tā·shən]
(genetics)
Mutation of a single gene due to addition, loss, replacement, or change of sequence in one or more base pairs of the deoxyribonucleic acid of that gene.
References in periodicals archive ?
Such a change would address about half the 32,000 known point mutations that cause disease.
Inverse mutation and single point mutation are applied to generate improved chromosomes for obtaining the best objective value.
Six specimens had an ompA genotype identical to the L2 reference strain L2/434/Bu, and 7 had a novel genotype that differed from the L1 reference strain L1/440 by 9 point mutations.
RFLP assay was used in the present study as it is a simple, rapid and cost-effective technique for detecting point mutation at codons 55 and 57 in the DHPS gene of P.
Based on an idea by Joshua Plotkin, a junior fellow in the Faculty of Arts and Sciences at Harvard, the researchers focused on the susceptibility of codons (nucleotide triplets constituting the genetic code) to point mutations (modification of a single DNA nucleotide) and the fact that not all point mutations produce the same results.
But a mismatch of one nucleotide, at the point mutation linked to the disease, activated the cellular DNA repair enzymes to fix the defective gene.
7 PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON B, Hughes and Federica Verra, a parasitologist and Coluzzi's colleague in Rome, found a large number of point mutations in 23 locations in the P.
For each DNA sample from a patient, the two PCR reactions for each point mutation locus were run in two separate lanes on the gel (Fig.
When the mutated gene was translated into a protein, the point mutation led to the substitution of methionine for lysine as the 27th amino acid in this variant of histone H3 protein.
One such reassortment event (shift), rather than a point mutation (drift), appears to explain the emergence of the A/Fujian/411/2002-like strain that caused an epidemic during the 2003 2004 influenza season.