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polybasic |
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polybasic [¦päl·i‚bā·sik] (chemistry) A chemical compound in solution that yields two or more H-ions per molecule, such as sulfuric acid, H2SO4. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Whether further selection will occur against the polybasic cleavage site in the HA and the pathogenicity determining sites in PB2 and NS remains to be seen. An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans. The HA gene contained a glutamine at position 222 (226 in H3) in HA1 and 4 polybasic amino acid insertions at the cleavage site, which had also been found in other recent H5N1 isolates from chicken and tigers (1,2). |
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