polyene


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polyene

[′päl·ē‚ēn]
(organic chemistry)
Compound containing many double bonds, such as the carotenoids.
References in periodicals archive ?
Structure-Antifungal Activity Relationships of Polyene Antibiotics of the Amphotericin B Group.
The systemic antifungal classes currently available are polyenes, triazoles, echinocandins, and flucytosine.
This resulted in the formation of polyene structures in the chain due to elimination of HCL, if exposed to high temperature or high mechanical stress.
An early example of what this process could lead to is Burke's work on one particular polyene compound, an extremely valuable but also highly toxic antifungal drug called amphotericin.
Among alkenes, mono-alkene constituted the largest proportion, while the ratio of alkadiene and polyene was quite small.
43) The polyene, Natamycin is usually the initial agent of choice and has shown to be more effective than the azole, Voraconazole for filamentary fungus, such as Fusarium and Aspergillus, (44) the most common agents in trauma and contact lens related disease.
2]O blends reveal two-stage degradation: the first stage attributes to the volatilization of hydrogen chloride molecules followed by the formation of the conjugated polyene sequences with the temperature range from 260[degrees]C to 360[degrees]C, whereas the second stage corresponds to the thermal cracking of the carbonaceous conjugated polyene sequences with the temperature range from 400[degrees]C to 500[degrees]C.
Organization of polyene antibiotic amphotericin B at the argon water interface.
Dendralenes are polyene hydrocarbon in which carbon-carbon double bonds are aligned in cross conjugated arrangement and require the presence of at least three carbon-carbon double bonds [1].
binding to meth-yl-beta-cyclodextrin [m[beta]cd] or polyene antibiotics, respectively), enzymatic reduction, or inhibition of CHOL biosynthesis adversely affects all fusion parameters (i.
Cyclization results in steric hindrance between the methyl group at C-5 of the ring and the hydrogen atom at C-8 of the polyene chain.