polygenic


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Related to polygenic: polygenic disease, polygenic disorder, Polygenic traits

polygenic

[¦päl·i¦jen·ik]
(geology)
References in periodicals archive ?
Pathophysiologic mechanisms of stones are complex, mainly because stone disease is a polygenic, multifactorial disorder that involves an interrelationship between the kidney, bone, and intestine.
This system is especially useful when inheritance of the resistance is polygenic, or determined by many genes, and backcrossing systems are consequently less effective.
15,16) However, experts agree that inheritance of a tendency toward obesity is usually not due to a single gene defect but is, instead, polygenic.
But the number of polygenic diseases for which one can actually find all the responsible genes has not increased significantly, because there are complex interactions between the human genome and also the environment.
There is developing interest in polygenic low-penetrant genes that may be influenced by environmental factors, although the actual contribution of such genes to breast cancer pathogenesis remains elusive.
A number of cases are now recognised as familial, and within affected families the disorder exhibits either an autosomal recessive pattern of inheritance or a polygenic inheritance pattern, ie involving several genes and the environment.
c) A polygenic trait may have several different phenotypes and genotypes.
For quantitative traits determined by multiple genes, this approach allows researchers to dissect the polygenic effects because each ISCS carries only one specific QTL-containing region (Darvasi 1997).
It is this reputation of the antioxidants in the mainstream of pharmaceutical research that has attracted the scientific community and increased the popularity as an alternative new generation therapeutic approach for the management of diverse polygenic disorders of humans (Tiwari 2004).
This core concept has current relevance but needs to be modified to accommodate the polygenic nature of obesity and that it arises through the joint interactions of multiple genetic and environmental factors (Loos and Bouchard, 2003).
These possibilities were investigated on three experimental models of hypertension: (1) the SHR, a well-established phenotype-driven model of polygenic hypertension attributed to both neural and vascular alterations (Lerman et al.