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polykaryocyte

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polykaryocyte [¦päl·i′kar·ē·ə‚sīt]
(cell and molecular biology)


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3) The following can also be observed: proteinaceous deposits in germinal centers, vascularization of germinal centers (Figure 1), necrosis of germinal centers, polykaryocytes (Warthin-Finkeldey-type giant cells), eosinophils in germinal centers, eosinophilic folliculolysis, eosinophilic microabscesses, postcapillary venule proliferation, stromal sclerosis, perivenular sclerosis, rare giant cells (Warthin-Finkeldey-type giant cells), or small eosinophilic granulomas.
Their characteristic histologic features include preserved nodal architecture, florid follicular hyperplasia with reactive germinal centers, protein and IgE deposits in germinal centers, germinal center necrosis, eosinophilic infiltrates, proliferation of post-capillary venules, sclerosis, polykaryocytes, eosinophilic folliculolysis, and prominent eosinophilic microabscesses (figure).
Monoclonal antibodies to gp100 inhibit penetration of human herpesvirus 6 and polykaryocyte formation in susceptible cells.
 
 
 
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