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polysomy

   Also found in: Dictionary/thesaurus, Medical, Wikipedia 0.01 sec.
polysomy [päl·ē‚sō·mē]
(genetics)
The occurrence in a nucleus of an extra copy of one or more individual chromosomes.
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The scoring systems used for increased ploidy are subjective and in many cases it may reflect general genomic instability rather than a specific EGFR gene amplification or chromosomal polysomy.
Targeted Therapy in Non-Small Cell Lung Cancer: A Commentary by Bruno Murer / Archives of Pathology & Laboratory Medicine
Also, colorectal tumours distinguishable by fluorescence in situ hybridisation (FISH) analysis of EGFR as homogeneously disomic or with low chromosome 7 polysomy have a reduced response rate to panitumumab [5].
Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line ... by Carrato, Alfredo; Guillen-Ponce, Carmen / Advances in Gastrointestinal Cancer
In addition to the diagnostic t(12;22), polysomy of chromosome 8 has been observed as a secondary abnormality in many cases of CCSTA.
Clear cell sarcoma of tendons and aponeuroses: a review by Dim, Daniel C.; Cooley, Linda D.; Miranda, Roberto N. / Archives of Pathology & Laboratory Medicine
 
 
 
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