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positional cloning

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positional cloning [pə¦zish·ən·əl ′klon·iŋ]
(genetics)
The identification of a gene and its isolation as a cloned deoxyribonucleic acid fragment, starting from knowledge of its position on a genetic map or chromosome.


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The gene responsible for the trait is then identified through positional cloning.
Covered methods--adaptable to studying the genetic components of other conditions--include bioinformatics, cytogenetic analyses, mutation screening, microarray analysis, positional cloning, and recording and mapping of cardiac physiology.
GEFS+ was identified using positional cloning, which is currently the most useful genetic technique to identify families with many affected individuals, he said.
 
 
 
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