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posttranslational modification

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posttranslational modification [‚pōs·tranz¦lā·shən·əl ‚mäd·ə·fə′kā·shən]
(cell and molecular biology)
Any polypeptide alteration that occurs after synthesis of the chain.
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Here modification residue means a specific posttranslational modification activity at residues in proteins, for instance a hydroxyproline residue means a proline which can be hydroxylated and has been confirmed in experiments.
The pattern of co-existed posttranslational modifications-a case study by Yang, ZHeng-Rong / Journal of Biomedical Science and Engineering (JBiSE)
Whereas protein drugs such as insulin and growth hormone are produced in bacterial cell lines, more complex proteins like erythropoietin or monoclonal antibodies have to be expressed in mammalian cell lines, as their activity depends on correct assembly and posttranslational modification.
Protein characterization: Katja Aschermann and Andreas Wattenberg, ... by Aschermann, Katja; Wattenberg, Andreas / Pharma
Often, the newly formed protein is inert until made functional by a posttranslational modification such as phosphorylation or proteolytic cleavage.
Basic Concepts of Molecular Pathology by Timothy Craig Allen and Philip T Cagle and Helmut H Popper / Archives of Pathology & Laboratory Medicine
 
 
 
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