Also found in: Dictionary, Medical, Wikipedia.
Related to Precancer: precancerous, precancerous lesion



pathological changes that precede the development of a malignant tumor.

The concept of “precancer” was first formulated with regard to skin cancer, which is the most accessible to clinical observation. Later, precancer was diagnosed in the lower lip, breasts, cervix of the uterus, and stomach. Research in experimental oncology has demonstrated that precancerous conditions differing in clinical manifestations represent the same basic pathological process with the same definite pattern.

There are three stages of precancer generally distinguished in Soviet oncology. In the stage of uneven diffuse hyperplasia, the tissue retains its normal structure, but the number of its structural elements, such as cells and fibers, increases. In the stage of focal proliferation, the total mass of multiplying cells contains areas, or foci, in which the cells divide with unusual rapidity. In the comparatively benign tumor stage the foci of multiplying cells steadily cease to resemble the original tissue and become increasingly isolated but do not exhibit a tendency toward invasive growth—that is, growth into and destruction of healthy tissue. The first stage is not yet precancer in the strict sense of the word. The second stage is the most characteristic stage of a precancer. The third stage is not essential, since the cancer can bypass it and continue developing. A precancer can regress or cease developing for a long time.


Shabad, L. M. Predrak v eksperimental’no-morfologicheskom aspekte. Moscow, 1967.
References in periodicals archive ?
They clearly showed that the cytology component to cotesting performance over many years is very limited for detecting precancers and early curable cancers.
8 percent overall increase in the detection of cervical precancers, and time to detection was much shorter (a median of 103 days versus 393 days).
define early intervention, precancer, and three levels of prevention
Women over age 65 years who have been screened regularly with normal results do not require screening, but those over age 65 years who are diagnosed with cervical precancer should continue to be screened, the ACS guidelines say.
The clinical trial, called the DeeP-C study, included 10,000 patients and was designed to determine how well Cologuard detects precancer and cancer.
If more oral spots are tested to rule out the presence of precancer or cancer, the incidence rate of this disease would drop dramatically.
Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women.
For example, rather than taking a few biopsies from random sites to represent a large heterogeneous lesion, our system can guide the clinician to biopsy the tissue with the worst state of disease to provide a more accurate diagnosis, as opposed to possibly missing the cancer or precancer.
A study published in Digestive Diseases and Sciences concluded that by using the WATS biopsy during a routine endoscopy, physicians can increase their detection of still harmless precancer in the esophagus by up to 40 percent.
Medicis products fight acne, precancer skin growths and skin-related viruses.
The precancer risk of betel quid chewing, tobacco use and alcohol consumption in oral leukoplakia and oral submucous fibrosis in southern Taiwan.