Alternatively, low expression of miR-200c in the primary tissue might reflect changes taking place in the primary tumor associated with EMT that facilitate exit from the primary tumor, a process that is later reversed in the metastatic deposit.
In conclusion, this first direct-comparison study of miRNAs expression in CTCs, corresponding plasma, and paired primary tissues demonstrates that: (a) metastasis-related miRNAs are overexpressed in CTCs and corresponding plasma, (b) miR-21 expression levels are highly correlated in CTCs and plasma, and (c) miR-21, miR-146a, and miR-210 are valuable plasma biomarkers for discriminating patients from healthy individuals.
In the current study, fibroblastlike cells were found to grow and expand from the periphery of the primary tissue
how to establish a primary tissue
culture, where cells are taken directly from an organ of ,a living animal.
The cutoff (for 95% specificity) derived from the data on metastatic tissue was slightly higher than that for primary tissue data, but the distributions of serum HER2 in the negative (primary tissue vs metastatic tissue) and positive tissue HER2 group showed no significant difference by t-test (P = 0.
The cutoff determined from metastatic tissue data was slightly higher than that of primary tissue data, but we observed no significant difference of serum HER2 between each of the negative (primary tissue vs.
7 Designer Cells Derived from Primary Tissue
and Designed Cell Lines as a Sustainable Cell Source for Drug Discovery and Safety Assessment (Volker Sandig and Ingo Jordan).
Current in vitro models of liver function employ immortalized cell lines, animal models and primary tissue
isolates harvested from human cadavers.
Previously, researchers have been unable to transduce non-dividing cell types, neurons, macrophages, and other primary tissue
types crucial for studying genes as targets against novel therapeutics.
Aidan Courtney, CEO of Roslin commented that "The characterization of both primary tissue
and of cells in culture is fundamental to our operation.
Particular attention was paid to the initials, the primary tissues
(epidermis, ground tissue, the vascular tissue) as well as the activities of the primary tissues
leading to secondary thickening of the stem.
The nerves of the brachial plexus are the primary tissues
injured, so specialists in pediatric neurology and rehabilitation medicine must evaluate the patient to determine what level of surgery and rehabilitation is required.