proband


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Related to proband: propositus, consultand

proband

[′prō‚band]
(genetics)
The clinically affected individual through whom a family is found that can be used to study the genetics of a particular disorder. Also known as propositius.
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A Carolingian capitulary describing cold water ordeals required a knot to be made in the rope attached to the proband at a prescribed length from his body, defining the depth to which he had to sink to prove his innocence.
Laboratories should create a policy around requirements for consent to be provided along with the request for WES testing for a proband and/or trio.
However, the patient was counseled about the possible association of optic neuritis and schwannoma with the underlying CMT disease and the need for urgent medical attention in the case of the development of sudden motor deterioration or focal neurological abnormalities in the proband or affected relatives.
All the probands studied were compared with respect to their parental education, occupation, religion, presence of consanguineous relationship in parents and degree of consanguinity and accordingly classification of probands was done.
Hence, we have assessed the levels of clinical severity, biochemical markers, and dystrophin gene deletion pattern in indexed BMD proband by visual examination, fully automated biochemical analyzer, and M-PCR using 26 exons multiplex reaction, respectively.
Assessing the agreement between the diagnosis of depression based on information Provided by the Proband comPared to the diagnosis based on information provided by other informants (Table 1), the Kappa coefficient is computed as follows:
The proband exhibited biconvex deformity with anterior beaking of the vertebral bodies, but platyspondyly was not evident.
Mutual interaction of proband with their external and internal environment is reflected in their mental state.
This and the coaching of the probands during the study was performed by a team consisting of a nutritionist, a diabetologist, a physician specialized in nutrition, and an educationalist.
Because all sibs of the proband are at risk of developing retinoblastoma, they periodically undergo a series of clinical examinations including Examination Under Anesthetic (EUA) to diagnose and treat tumors as early as possible.