Progestins

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Related to progestin: progesterone

Progestins

 

gestagens, a group of substances with properties of the female sex hormone, progesterone (the hormone of the corpus luteum), and of the products of its metabolism.

Progestin are found in the corpus luteum, the placenta, ovaries, adrenals, and blood of humans and other mammals. The male sex glands also contain a certain amount of progestins. They exert influence on the mucous membrane of the uterus during pregnancy, ensuring normal development of the embryo. Substances exhibiting progestin-like activity have been obtained by chemical synthesis. Some of them (progesterone, pregnin) are used in medicine.

References in periodicals archive ?
XBIO-101, Xenetic's lead product candidate in development, is a small-molecule immunomodulator and interferon inducer which, in preliminary studies, has been shown to increase progesterone receptor (PrR) expression in endometrial tumor tissue which may re-sensitize endometrial tumor tissue to progestin therapy in previously unresponsive tumors.
By type of contraceptive, the percent of women who reported that the contraceptive made their acne worse was: LNG-IUD, 36%; progestin implant, 33%; depot medroxyprogesterone acetate (MPA), 27%; levonorgestrel-ethinyl estradiol oral contraceptive, 10%; norgestimate-ethinyl estradiol (EE), 6%; etonogestrel-EE vaginal ring, 4%; drospirenone-EE, 3%; and desogestrel-EE, 2%.
Restoration of PrR expression may re-sensitize endometrial tumor tissue to progestin therapy in previously unresponsive tumors.
Combined oral contraceptives (COCs): COCs all contain an estrogen and a progestin.
5), estrogen with or without progestin led to a 40% lower risk for incident CHD [RR, 0.
If you miss periods and can't take either combination or progestin-only birth control pills, or would simply prefer not to take them, you may need an occasional progestin prescription to balance the unopposed estrogen.
Los Angeles Biomedical Research Institute (LA BioMed) lead researcher and colleagues, looked at postmenopausal women, who had no prior hysterectomy with negative mammograms within two years and were either users or non-users of estrogen and progestin combined therapy.
A long" duration of treatment, especially [with] the combination estrogen plus progestin, substantially increases breast cancer risk and may even increase the risk of lung cancer.
However, those findings also indicate that women who take estrogen plus progestin continue to be at increased risk of breast cancer, even years after stopping therapy.
035 mg or less of ethinyl estradiol), and 10% had taken pills with a low concentration of progestin (less than 0.
Progestin prevents the overgrowth of cells in the lining of the uterus, which can lead to uterine cancer.
As levels of progestin in the pills decrease, menstruation occurs.

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