30 /PRNewswire/ -- The first hormone replacement therapy (HRT) to combine both estrogen and progestin
in a single transdermal (through the skin) patch is now available for menopausal women with an intact uterus for the relief of moderate-to-severe vasomotor symptoms such as hot flashes, night sweats and vaginal dryness.
Preliminary validation of these results will be conducted in a separate set of cases and controls from the same OS cohort, and a final validation and replication will also focus on the interactions of the disease-associated SNPs with the combined estrogen plus progestin
(E+P) therapy in samples from the randomized controlled clinical trial cohort (CT).
While the risk of developing lung cancer for women using estrogen plus progestin
HRT 10 years or longer was approximately 50 percent more than women not using HRT, this risk is actually quite small compared to the risk from smoking.
It pools both the estrogen only and the estrogen plus progestin
data, and both groups are completely consistent--showing the same risk for probable dementia.
28) Oral desogestrel with testosterone pellets was recently found to lead to azoospermia, but requires daily administration of the progestin
and a minor procedure for insertion of pellets.
The writer of the original letter, Phyllis Bronson, had caught her error about progestin
and mares' urine.
One NIH study -- the Women's Health Initiative Memory Study, or WHIMS -- recently showed that taking a combination of estrogen and progestin
actually increased the risk of dementia in women.
Taylor said that breast and uterine cells won't be stimulated by the estrogen plus SERM combination, so women in menopause get the benefits of estrogen without the risk of progestin
Two types of intrauterine devices (IUD) also provide long-acting, reversible contraception in part by releasing progestin
directly into the uterine lining.
Maxwell and his colleagues used the CASH data to examine the relationship between progestin
and estrogen potency in combination OCPs in 434 women with endometrial cancer and 2,557 controls.
OCP users were defined as having used OCPs for at least 12 months and were divided into four cat egories by type of pill use: high estrogen and progestin
; high estrogen/low progestin
; low estrogen and progestin
; and low estrogen high progestin
In contrast, women who had used only regimens containing both estrogen and progestin
did not have a significantly elevated risk, although data were limited for this group.