trypanosome

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Related to promastigote: amastigote, epimastigote, trypomastigote

trypanosome

(trĭp`ənəsōm'), microscopic, one-celled protozoan of the genus Trypanosoma, typically living as an active parasite in the bloodstream of a vertebrate; hundreds of species are known. A trypanosome is long and pointed and possesses a flagellum. The flagellum arises at the front, or anterior, end of the parasite and curves back to form the edge of a long, undulating membrane used in locomotion. Trypanosomes have a complex life cycle; most species undergo part of their development in the digestive tract of insects, which spread the parasite by biting.

Many trypanosomes do not appear to harm their hosts, but a number of species cause serious diseases in humans or domestic animals (see trypanosomiasistrypanosomiasis
, infectious disease caused by a protozoan organism, the trypanosome, which exists as a parasite in the blood of a number of vertebrate hosts. The three variations of the disease that predominate in humans are transmitted by an insect vector.
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). T. brucei gambiense and T. brucei rhodesiense cause African sleeping sickness and are transmitted by tsetse fliestsetse fly
, name for any of several bloodsucking African flies of the genus Glossina, and in the same family as the housefly. The larva of the tsetse fly develops inside the body of the mother until it is ready to pupate in the soil.
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. T. cruzi is the cause of Chagas' diseaseChagas' disease,
disease of South and Central America caused by the parasite Trypanosoma cruzi. It usually affects children and young adults and is transmitted by the feces of infected insects, typically the assassin bug.
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, prevalent in South and Central America, which affects the nervous system and heart; it is transmitted by the bite of assassin bugsassassin bug,
common name for members of the family Reduviidae, one of the largest and most varied groups belonging to the order Hemiptera (suborder Heteroptera). Assassin bugs are generally brownish to black, medium-sized to large insects, with heads that are elongate and
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. Other species, restricted in distribution to Africa and Asia, cause diseases of horses and cattle. Control measures include elimination or reduction of the insect carrier populations and measures to reduce the likelihood of bites.

Trypanosomes are classified in the phylum Mastigophora of the kingdom ProtistaProtista
or Protoctista
, in the five-kingdom system of classification, a kingdom comprising a variety of unicellular and some simple multinuclear and multicellular eukaryotic organisms.
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.

trypanosome

[trə′pan·ə‚sōm]
(invertebrate zoology)
A flagellated protozoan of the genus Trypanosoma.
References in periodicals archive ?
cajucara terpenes (DCTN, CTN and AAA) obtained from the bark of this Croton species, against promastigotes, axenic and intracellular amastigotes of Leishmania amazonensis.
For integration of the expression cassette into the 18S ribosomal RNA (ssu) locus, the pLEXSY-hyg2 plasmid containing LPG3 gene was digested by SwaI restriction enzyme (Fermentas, Lithuania) and 10 [micro]g of the heavier fragment was transformed into cultivated Lizard Leishmania promastigotes by electroporation in vitro.
All samplings were cultured at 25oC in rabbit blood agar and considered negative if no promastigotes were visible during a two months period.
Las formas promastigotes del parasito invaden las celulas del sistema reticulo-histiocitario, se reproducen bajo la forma de amastigotes y luego se diseminan por via linfatica o por via sanguinea para localizarse en los macrofagos de la medula osea, el higado y el bazo, cuyo compromiso gradual, cronico, llega a ser masivo, lo cual exphca las manifestaciones clinicas de la enfermedad.
Inhibition of Leishmania donovani promastigote internalization into murine macrophages by chemically defined parasite glycoconjugate.
The other phase, the promastigote phase, develops in the stomach and lower intestine of the mosquito, and consists of elongated cells, 10-25 mm long, slightly thicker at the middle, and with a single apical flagellum.
7nM, respectively) were able to detect LiPABP from only 2500 parasites, which is a promising result for the development of a sensitive method that would detect LiPABP in both promastigote and amastigote forms of Leishmania.
According to the company, miltefosine is an alkyllysophospholipid analogue drug with in vitro activity against the promastigote and amastigote stages of Leishmania species.
Previous studies also showed that cardamonin is highly active against promastigote and amastigote forms of L amazonensis (Ruiz et al.
Protection of mice against visceral leishmaniasis by immunization with promastigote antigen incorporated in Liposomes.