Prophase

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prophase

[′prō‚fāz]
(cell and molecular biology)
The initial stage of mitotic or meiotic cell division in which chromosomes are condensed from the nuclear material and split logitudinally to form pairs.

Prophase

 

one of the stages of mitotic cell division. During prophase of mitosis, the mitotic apparatus is formed and the chromosomes, which already consist of two sister chromatids, spiralize. In most cells, the nuclear membrane fragmentizes and the nucleolus is destroyed during prophase.