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proteolysis |
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proteolysisProcess in which a protein is broken down partially, into peptides, or completely, into amino acids, by proteolytic enzymes, present in bacteria and in plants but most abundant in animals. Proteins in food are attacked in the stomach by pepsin and in the small intestine mainly by trypsin and chymotrypsin from the pancreas. Proteolytic enzymes are secreted as zymogens, which are themselves converted by proteolysis to their active forms. Many other zymogens or precursors undergo proteolysis to form active enzymes or proteins (e.g., fibrinogen to fibrin). In cells, proteolytic degradation of old proteins is part of cellular maintenance. proteolysis [‚prōd·ē′äl·ə·səs] (biochemistry) Fragmentation of a protein molecule by addition of water to the peptide bonds. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Although purifying large amounts of pilus-associated adhesin is difficult (because most adhesins are proteolytically degraded when expressed as independent moieties), Hultgren et al. These MIDAS molecules are simple to synthesize, chemically and proteolytically stable, and have the potential to be orally bioavailable. |
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