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proto-oncogene |
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proto-oncogene [¦prō·dō ′äŋ·kōjēn] (genetics) The normal-functioning precursor of an oncogene; mutation of this gene to produce an oncogene causes excessive activity of the gene product, leading to cancer. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Normal thyroid follicular cells, follicular neoplastic cells, and thyroid follicular cells in benign nodular hyperplasia do not express the RET proto-oncogene. 2]-responsive genes, lactotransferrin (LTF; Liu and Teng 1992) and the proto-oncogene C-FOS (Weisz and Bresciani 1988), demonstrate that [E. Indeed, various genetic lesions are present in many of these tumors, causing activation of the c-myc (especially in Burkitt's type lymphomas), bcl-6 and ras proto-oncogenes and inactivation of the p53 tumor suppressor gene. |
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