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proto-oncogene

   Also found in: Dictionary/thesaurus, Medical 0.01 sec.
proto-oncogene [¦prō·dō ′äŋ·kōjēn]
(genetics)
The normal-functioning precursor of an oncogene; mutation of this gene to produce an oncogene causes excessive activity of the gene product, leading to cancer.


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Here we present the results of our computational analysis of oncogene and proto-oncogene proteins and the rational design of bioactive peptide analogues having the oncogenic or proto-oncogeneic-like activity.
The other topics are polyunsaturated fatty acid deficiency, the correlation between vascular endothelial growth factor and proto-oncogene c-fos and c-myc, and the expression of neural cell adhesion molecules and osteonectin.
Analysis of RET proto-oncogene mutation at codon 918 should be performed in all children born to parents with MEN 2B, as well as in children with ambiguous clinical features suggestive of MEN 2B.
 
 
 
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