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proto-oncogene

   Also found in: Dictionary/thesaurus, Medical 0.03 sec.
proto-oncogene [¦prō·dō ′äŋ·kōjēn]
(genetics)
The normal-functioning precursor of an oncogene; mutation of this gene to produce an oncogene causes excessive activity of the gene product, leading to cancer.


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Normal thyroid follicular cells, follicular neoplastic cells, and thyroid follicular cells in benign nodular hyperplasia do not express the RET proto-oncogene.
2]-responsive genes, lactotransferrin (LTF; Liu and Teng 1992) and the proto-oncogene C-FOS (Weisz and Bresciani 1988), demonstrate that [E.
Indeed, various genetic lesions are present in many of these tumors, causing activation of the c-myc (especially in Burkitt's type lymphomas), bcl-6 and ras proto-oncogenes and inactivation of the p53 tumor suppressor gene.
 
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