Published in the latest issue of the journal Nature Structural & Molecular Biology, the team's findings suggest a much larger role for pseudogenes
than previously thought -- a discovery that changes our understanding of the internal landscape of living cells, adding a new layer of complexity to an already crowded topography marked by multiple, overlapping, interacting gene networks.
Exclusion of BRAF, KRAS, and PIK3CA Pseudogene
Part of the issue with the clinical validation stemmed from the fact that this region of the PMS2 gene contains the PMS2CL pseudogene
, which complicates an accurate analysis.
By this multiplex PCR, rearrangement of both NEMO gene and pseudogene
It is unclear why the C allele increased probability of the disease, given that CYP3A43 has been suggested to be a pseudogene
, (4) having a specific role of contributing exons to CYP3A5 and CYP3A4 transcripts to produce hybrid mRNAs.
Identification of a novel cytokeratin 19 pseudogene
that may interfere with reverse transcriptase-polymerase chain reaction assays used to detect micrometastatic tumor cells.
Conversion mutations due to recombination of SBDS with SBDSP resulting in unidirectional gene conversion from the pseudogene
to SBDS have been shown to be responsible for disease (Figure 2).
Several unique characters are observed in the Angiopteris plastid genome, such as repeat structure in a pseudogene
influenzae and proposed as a candidate NTHI vaccine antigen, is present as a pseudogene
in F3031 and F3047, as previously reported by Kilian et al.
Pandolfi's group found that RNA from a pseudogene
called PTENP1 draws tiny regulatory molecules called microRNAs away from PTEN, a powerful anticancer gene.
The BoLA-DRB3 locus is expressed at high levels while DRB1 is expressed at a low level; DRB2 is a pseudogene
(Burke et al.
This situation is often due to the second allele being a pseudogene
with a sequence that has an early stop codon or a gene with a faulty promoter.