pseudogene


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pseudogene

[′sü·dō‚jēn]
(genetics)
A sequence of deoxyribonucleic acid resembling but not functioning like a gene; usually produced by gene duplication followed by mutations that alter or abolish function.
References in periodicals archive ?
elegantissima, which were based exclusively on RFLP and DGGE analysis of the nuclear ribosomal locus, were misled by intragenomic pseudogene diversity?
By this multiplex PCR, rearrangement of both NEMO gene and pseudogene is detected.
Pandolfi reasoned that the microRNAs attracted to PTEN wouldn't be able to tell gene from pseudogene, and that some microRNAs might go after the mRNA of PTENP1, leaving less to block PTEN.
Phylogenetic relationships among brazilian howler monkeys genus Alouatta (Platyrrhini: Atelidae) based on [gamma]1-globin pseudogene sequences.
A fast real-time polymerase chain reaction method for sensitive and specific detection of the Neisseria gonorrhoeae porA pseudogene.
However, the insertions and deletions leading to pseudogene formation were not shared between the two closely related tailless species, supporting the hypothesis that they evolved independently from a tailed ancestor.
All these species have adapted to their host niches and as a result, may have lost the need for many proteins, so: "Every genome should be viewed as a work in progress, burdened with some non-functional #baggage of history,' " despite the fact that in the past bacteria were thought to be free of the pseudogene "baggage" found so commonly in eukaryotes (Pallen & Wren, 2007, p.
Implications of high level pseudogene transcription in Mycobacterium leprae.
In addition to suggesting a new weapon in the battle against AIDS, this so-called pseudogene reignites speculation about why infection with HIV kills people but not nonhuman primates.
Utilizing public pseudogene databases, Compugen's predictive methodology has been shown to both verify the sequences' annotation on the genome and then use the pseudogene sequences as "blue prints" for new gene variants and, therefore, novel transcripts and proteins.
Visual inspection of variant calls in the IGV was performed looking for the issues listed above (G-C rich areas, pseudogene or INDEL mismapping, and hemizygous mutations).
Wholegenome sequencing of ST313 strains has shown genome degradation, including pseudogene formation and chromosomal deletions as have been observed for human-restricted S.