pyrazinamide


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Related to pyrazinamide: ethambutol

pyrazinamide

[‚pir·ə′zin·ə‚mīd]
(pharmacology)
C5H5N3O A crystalline compound with a melting point of 189-191°C; used as a drug in the treatment of tuberculosis.
References in periodicals archive ?
Mutations Associated with Pyrazinamide Resistance in pncA of Mycobacterium tuberculosis Complex Organisms.
Drugs responsible for these gastrointestinal (GI) side effects included, Pyrazinamide, Rifampicin and Isoniazid.
Choose any available and Rifampicin/rifabutin potentially effective drugs Isoniazid from Group 1 Pyrazinamide Ethambutol 2.
During the second week of treatment, pyrazinamide was stopped and ethambutol added as the aspartate aminotransferase (AST) was 685 IU/L and alanine aminotransferase (ALT) 405 IU/L; the INH and rifampicin doses were reduced.
Determination of rifampicin and its main metabolite in plasma and urine in presence of pyrazinamide and isoniazid by HPLC method.
DISCUSSION: Isoniazid, rifampicin and pyrazinamide have been observed to have hepatotoxic potential and drug induced hepatotoxicity (DIH) is an important and commonly encountered adverse effect with anti TB treatment (2, 3) Several types of drug induced liver damage have been described.
For TB disease, patients currently take up to 11 tablets a day as part of a four-drug regimen (2 rifampin 300 mg, 1 INH 300 mg, 4 pyrazinamide 500 mg, and 4 ethambutol 400 mg tablets).
The standard short-course chemotherapy for treatment of cutaneous tuberculosis which involves the administration of three antituberculous drugs for the first two months (isoniazid 10 mg/Kg, rifampicin10 mg/Kg, pyrazinamide 30 mg/Kg), followed by four months of isoniazid and rifampicin was started.
The adults were started on standard, directly-observed therapy (DOT) with rifampin, isoniazid, ethambutol, and pyrazinamide for active pulmonary TB disease.
It was recognized in the 1970s that isoniazid and rifampicin could reduce the duration of treatment from 18 to 9 months; and the observation in the 1980s that adding pyrazinamide to these drugs allowed cures in only 6 months2.
Treatment regimen: The standardized regimen consisted of an intensive phase (IP) of 6-9 months with 6 drugs, namely kanamycin (Km), ofloxacin (Ofx), ethionamide (Eto), pyrazinamide (Z), ethambutol (E), and cycloserine (Cs) given daily.
TB treatment--rifampicin, isoniazid and pyrazinamide may cause a hypersentivity reaction with flu-like symptoms and uticaria.