pyrogen


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Related to pyrogen: endotoxin, endogenous pyrogen

pyrogen

[′pī·rə‚jən]
(biochemistry)
A group of substances thought to be polysaccharides of microbial origin that produce an increase in body temperature when injected into humans and some animals.
References in periodicals archive ?
Pyrogen testing is carried out at all levels of pharmaceutical and biopharmaceutical manufacturing process to minimize the risk of product contamination.
When performing pyrogen testing in pharmaceutical products, the complexity of the human response must be considered.
The Rabbit Pyrogen (Material Mediated) - ISO Test was performed by Toxikon Corporation in Bedford, Massachusetts, USA.
Pyrogens inhibit heat-sensing neurons and excite cold-sensing ones, thereby altering the temperature sensors and deceiving the hypothalamus into thinking the body is cooler than it actually is.
Metal Storm's Chief Executive Officer Charles Vehlow said he was very pleased that the company's ongoing relationship with Pyrogen - an international fire protection company which distributes its products through a worldwide network of distributors and dealers - had progressed to this stage.
Both the LAL and IPT tests are designed to detect pyrogens, which are microbial contaminants such as bacteria, viruses, fungi and parasites that cause fever and illness in people.
Pyrogen Australia Pty Limited based in Sydney, Australia, is a subsidiary of Pyrogen Corporation, an international company marketing and distributing Pyrogen fire suppression products.
For 1:200 titres highest prevalent serogroup was canicola followed by pomona, autumnalis, icterohaemorrhagiae and pyrogens.
In order to maintain the integrity of such applications, the water used needs to be free from one or more of the commonly encountered contaminants: ions, trace organics, particles, bacteria, pyrogens, and importantly, nucleases, all of which can have a detrimental effect on resulting data.
Fevers are caused by chemicals called pyrogens flowing in the bloodstream.
Pyrogens are lipopolysaccharides found in the outer cell walls of certain bacteria.
In the vapor or steam phase, all other molecules are greatly restricted, so contaminants in water such as dissolved gases, ions, total organic carbons (TOCs), particles, viruses, bacteria, pyrogens, and metals can be removed from the purified steam.