1 PROFILE 1014 was a global, randomized
, open-label, two-arm Phase 3 study that evaluated the efficacy and safety of XALKORI in patients with previously untreated ALK-positive advanced NSCLC.
6) To build evidence to support the theory that a hospital window affording a view of nature is an effective intervention to provide comfort and to decrease surgical patients' length of stay in the hospital, we would design a prospective randomized
controlled trial using the same variables.
Researchers are especially fond of randomized
field trials when evaluating educational programs because they can increase the validity of their findings.
Over the past 40 years, cognitive therapy for depression has earned its stripes in randomized
controlled trials, concludes psychiatrist Aaron T.
controlled trial of misoprostol for second-trimester pregnancy termination associated with fetal malformation, American Journal of Obstetrics and Gynecology, 2004, 190(3):755-762.
Including all randomized
subjects when analyzing randomized
controlled trials--the "intention to-treat" principle--is an important factor in minimizing bias.
As far as can be determined from appendices in the report, only one of these studi es, involving a test of a specialized instructional strategy in the context of the Paideia program, depended on a randomized
conservation laryngectomy or radiation alone) might instead be treated with an intensive, toxic combination regimen that has not been proven to be superior in randomized
In a prospective, randomized
clinical trial of catheters in place for an average of 6 to 7 days, minocycline-rifampin-impregnated catheters were associated with lower incidence of infection than chlorhexidine-silver sulfadiazine-impregnated catheters (RR 0.
In this study 2527 patients were randomized
to receive Remune plus an adjuvant (a substance intended to increase the effect of the vaccine) or just the adjuvant as a control.
Underlying the debate was the expectation that the results of randomized
clinical trials reported at the ASCO meeting would finally provide scientific data to resolve the frequently emotional controversy.
Worse yet, they concluded that existing evidence that fat promotes breast cancer is too weak to justify any large-scale randomized
trial on fat and breast cancer.