Erythropoietin

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erythropoietin

[ə‚rith·rə′pȯi·ət·ən]
(biochemistry)
A hormone, thought to be produced by the kidneys, that regulates erythropoiesis, at least in higher vertebrates.

Erythropoietin

 

a hormone that stimulates the formation of erythrocytes in bone marrow. Characterized as a glycoprotein, erythropoietin has a carbohydrate content of 35 percent. It has a molecular weight of 30,000–40,000 and possesses antigenic properties. Erythropoietin is inactivated by neuraminidase, trypsin, chymotrypsin, and papain.

Erythropoietin was discovered by the French researchers F. Corneau and C. de Flandre in 1906 in rabbit serum that they tested after drawing blood. The hormone is found in low concentrations under normal physiological conditions, but the levels increase when the subject is in a state of hypoxia as a result of the loss of blood, a decrease in the oxygen content of the air, or various forms of anemia. Most scientists believe that erythropoietin is formed in the kidneys. When the hormone acts on stem cells in bone marrow, it causes their differentiation into cells of the erythroid series.

REFERENCES

Fedorov, N. A., and M. G. Kakhetelidze. Eritropoetin. Moscow, 1973.
Normal’noe krovetvorenie i ego reguliatsiia. Moscow, 1976.
Gordon, A. S. Regulation of Hematopoiesis, vol. 1. New York [1970].

N. A. FEDOROV

References in periodicals archive ?
Juul, "Pharmacokinetics of high-dose recombinant erythropoietin in plasma and brain of neonatal rats," Pediatric Research, vol.
They found that on the contrary, the risk that ROP would progress was significantly higher in those who received higher doses of recombinant erythropoietin than in those who received low doses or no erythropoietin.
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National Kidney Foundation, Ad Hoc Committee: Statement on the Clinical Use of Recombinant Erythropoietin in Anemia of End-Stage Renal Disease.
Recent studies of erythropoietin-stimulating agents (ESAs) have shown an increased risk of mortality arising from exposure to high levels of recombinant erythropoietin and its derivatives, which may stimulate tumor progression and increase the occurrence of thromboembolic events.
Contract notice: Providing Recombinant Erythropoietin In French Polynesia Hospital Centre
The anemia of chronic renal failure: Pathophysiology and the effects of recombinant erythropoietin.
Prosper Channel has a demonstrated track record of success opening up both domestic and international markets for its clients for various vaccines including but not limited to rubella, hepatitis, and measles and biological products including recombinant erythropoietin, granulocyte colony stimulating factor, interferon and somatropin.

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