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see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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γ-glutamyl cysteinyl glycine, a tripep-tide formed from radicals of three amino acids—glutamic acid, cysteine, and glycine. A peculiarity of the structure of glutathione is the peptide bond between cysteine and glutamic acid, in which the γ-carboxyl of the glutamic acid participates. Glutathione is present in all living organisms and is very important for oxidation-reduction reactions in connection with the capacity of the sulfhydryl group (SH—) of cysteine to undergo the reversible reaction

Glutathione can act as a coenzyme in the action of cathepsins, papain, and other proteolytic enzymes. The function of glutathione in metabolism apparently also includes the protection of the SH group of cytoplasm proteins against oxidation.


C10H17O6N3S A widely distributed tripeptide that is important in plant and animal tissue oxidation reactions.
References in periodicals archive ?
Mean[+ or -]SD values for liver thiobarbituric acid-reactive substances (lTBARS), reduced glutathione (lGSH), and myeloperoxidase (lMPO) and intestinal thiobarbituric acid-reactive substances (iTBARS), reduced glutathione (iGSH), and myeloperoxidase (iMPO) by group Group lTBARS lGSH (nmol/g wet tissue) ([micro]mol/g wet tissue) Control (n=8) 188.
Administration of reduced glutathione in FOLFOX4 adjuvant treatment for colorectal cancer: Effect on oxaliplatin pharmacokinetics, PtDNA adduct formation, and neurotoxicity.
The levels of serum vitamin C, malonyldialdehyde and erythrocyte reduced glutathione in chronic obstructive pulmonary disease and in healthy smokers.
Also, significant changes in variables (lactate, reduced glutathione, triglycerides, where Z value more than (+3, -3).
Study of serum MDA and reduced glutathione level in patients with Osteoarthritis 2013; 2:5682-7.
Levels of reduced glutathione, glutathione reductase and reduced glutathione s-transferase activities in rat lung and liver.
A highly significant increase mean value of reduced glutathione and decrease malondialdehyde from pre to post treatment (1.
They have found that chlorpromazine destabilized and increased the autooxidation of hemoglobin, induced activation of caspase 3, increased phosphatase PTP-1B activity, and, markedly, influenced the ATP and reduced glutathione levels, with subsequent exposure of phosphatidylserine at the erythrocyte surface.
Glutathione-S- transferase belonging to the detoxification system for Phase II cytosolic enzyme which catalyzes the conjugation of reduced glutathione to a variety of exogenous or endogenous electrophiles [16 and 18].
Reduced glutathione (GSH) plays a prominent role in the cellular defense against oxidative stress by scavenging ROS, both directly and as a substrate for GPx (9).

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