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the return of ill health after an apparent or partial recovery



a new exacerbation of a disease during remission after an apparent recovery. In the case of a latent chronic infection, for example, brucellosis, pneumonia, and erysipelas, a relapse may be caused by inadequate immunity, chilling, or the supervention of a secondary infection. It may also be caused by a faulty diet, for example, with colitis, or by the cyclical nature of the disease itself (malaria, relapsing fever). The pathogenic microflora of the body is usually activated as a result of a relapse. A repeated infection caused by the same microorganisms is called a reinfection.

The pathogenesis of a relapse of a noninfectious disease is caused by shock, for example, with eczema, by vascular disorders, by regular malignant growth, and by inadequate treatment, for example, by the incomplete removal of a tumor. The pathogenesis of a relapse is sometimes unknown, for example, with familial Mediterranean fever and schizophrenia.

The clinical symptoms of a relapse may resemble or differ from the onset of a disease as a result of both the nature of the disease and the prescribed treatment. A relapse is sometimes more severe than the first attack of a disease and is more difficult to treat, as in the case of a relapse of acute leukemia. A relapse may be accompanied by complications, for example, intestinal bleeding in typhoid. Relapses are common to some diseases, for example, chronic dysentery. Treatment and preventive methods for relapses are usually the same as for the original disease.


References in periodicals archive ?
Conclusion: Majority of the sustained responders had disease eradication, but non responders and relapsers should be followed for any evidence of cirrhosis.
By 3 months follow-up, we observed significant differences between abstainers and relapsers on both variables.
With one voice, the community 12-Step fellowships can come together with local treatment centers to help chronic relapsers find freedom.
3%) patients had shown undetectable HCV RNA during the therapy, but had become HCV RNA positive after discontinuing medication and were, thus, relapsers.
Invariably relapsers talked of the weakness and lethargy following the cessation of opium intake.
However, some authorities want to penalize relapsers.
We are extremely happy about the data from these phase III studies, which robustly demonstrate high cure rates in both treatment-experienced, so called relapsers, and treatment-naove patient groups, both including patients with severe liver disease.
Patients were categorized into Treatment naive, Relapsers and Non responders.
The study compared fMRI results of the subsequent relapsers with those of the abstainers.
Even if members don't meet the criteria for entering the "Centers of Excellence" program, which includes intensive case management and is expected to focus on frequent relapsers, they can still go to these programs, said Dennis.
These populations include adolescents, young adults, relapsers, people with chronic pain, impaired professionals, people with process addictions, and older adults.