relapse

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Related to relapsing: relapsing fever

relapse

the return of ill health after an apparent or partial recovery

Relapse

 

a new exacerbation of a disease during remission after an apparent recovery. In the case of a latent chronic infection, for example, brucellosis, pneumonia, and erysipelas, a relapse may be caused by inadequate immunity, chilling, or the supervention of a secondary infection. It may also be caused by a faulty diet, for example, with colitis, or by the cyclical nature of the disease itself (malaria, relapsing fever). The pathogenic microflora of the body is usually activated as a result of a relapse. A repeated infection caused by the same microorganisms is called a reinfection.

The pathogenesis of a relapse of a noninfectious disease is caused by shock, for example, with eczema, by vascular disorders, by regular malignant growth, and by inadequate treatment, for example, by the incomplete removal of a tumor. The pathogenesis of a relapse is sometimes unknown, for example, with familial Mediterranean fever and schizophrenia.

The clinical symptoms of a relapse may resemble or differ from the onset of a disease as a result of both the nature of the disease and the prescribed treatment. A relapse is sometimes more severe than the first attack of a disease and is more difficult to treat, as in the case of a relapse of acute leukemia. A relapse may be accompanied by complications, for example, intestinal bleeding in typhoid. Relapses are common to some diseases, for example, chronic dysentery. Treatment and preventive methods for relapses are usually the same as for the original disease.

A. A. SMIRNOV

References in periodicals archive ?
Compatible clinical disease descriptions have been documented since the time of Hippocrates; however, the term relapsing fever was first used by David Craigie to describe an outbreak of the disease in Edinburgh in 1843 (1).
During the first half of the 20th century, relapsing fever was a disease of major worldwide importance; it caused epidemics affecting [approximately equal to] 50 million and was associated with death rates of 10% to 40% (1).
Tickborne relapsing fevers may be endemic or sporadic.
Headquartered in Cambridge, MA, the company's revenues are generated from international sales of AVONEX (Interferon beta-1a) for treatment of relapsing forms of multiple sclerosis, and from the worldwide sales by licensees of a number of products, including alpha interferon and hepatitis B vaccines and diagnostic products.
Serodiagnosis of louse-borne relapsing fever with glycerophosphodiester phosphodiesterase (GIpQ) from Borrelia recurrentis.
Relapsing polychondritis; Prospective study of 23 patients and a review of the literature.
Head and neck manifestations of relapsing polychondritis: Review of 29 cases, Otolaryngology 1978;86:473-8.
A relapsing fever group spirochete transmitted by Ixodes scapularis ticks.
There are two general forms of relapsing fever, epidemic (louse borne--Pediculus humanus) and endemic (tick borne--Ornithodoros spp.
While clinical relapsing fever and Lyme disease differ from each other in many ways, their causative agents share many similarities at both the biologic and genetic levels.
Other relapsing fever [ILLEGIBLE TEXT] parkeri and B.
AVONEX, manufactured by Biogen Idec, was approved for relapsing forms of MS by the U.