renal clearance


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Related to renal clearance: renal clearance test

renal clearance

[¦rēn·əl klir·əns]
(physiology)
The volume of blood plasma completely cleared of a particular substrate by the kidneys per unit time, a measure of kidney function.
References in periodicals archive ?
The cardiac specific biomarkers cTnI, cTnT, BNP, and NT-proBNP are frequently increased in patients with CKD typically reflecting more cardiovascular pathophysiology than impaired renal clearance.
Desipramine, imipramine, and nortriptyline have nonspecific package insert recommendations for modified dosing in geriatric patients because of an age-related decrease in renal clearance.
Enoxaparin also has the smallest molecular weight, making its renal clearance the most prominent of the agents discussed (Table 1).
This structure creates a large sized molecule which reduces renal clearance and increases time- action profile.
Understanding the impact of altered pharmacokinetics and augmented renal clearance.
In vivo studies have demonstrated that cyclosporine inhibits hepatic and renal clearance of colchicine, thus increasing serum colchicine levels, further lowering the toxic colchicine dose.
Renal clearance studies in stubble quail Coturnixpectoralis and king quail Coturnix chinensis under conditions of hydration, dehydration, and salt loading.
The topics include pharmacokinetics, distribution, renal clearance, toxicity, and ADME screening.
Drugs that should be administered with caution in renal impairment fall into two categories: those with a moderate renal clearance but narrow therapeutic window (eg gentamycin, enalapril, digoxin), and those with wide therapeutic windows but high renal clearance (eg atenolol, penicillin, cephalosporins, enoxaparin).
In patients with sufficient blood ethanol levels, pulmonary and renal clearance become the major clearance pathway for methanol elimination.
Common adverse reactions reported in >=5% of patients treated with alogliptin plus metformin included upper respiratory tract infection, nasopharyngitis, creatinine renal clearance decreased, diarrhea, hypertension, headache and urinary tract infection.
Also, keep in mind that aging results in a number of physiological changes that will influence both pharmacokinetics and pharmacodynamics, including changes in body composition; decreases in gastrointestinal motility, hepatic metabolism, renal clearance, and protein binding; and increased central nervous system sensitivity to noxious stimuli and medication effects, Dr.