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repair synthesis

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repair synthesis [ri′per ‚sin·thə·səs]
(cell and molecular biology)
Enzymatic excision and replacement of regions of damaged deoxyribonucleic acid, as in repair of thymine dimers by ultraviolet irradiation.


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The recently dis- - and  elimination to generate 3 OH termini necescovered mammalian DNA glycosylase/AP lyases, NEIL1 sary for gap-filling repair synthesis by a DNA polymerase and NEIL2, unlike the previously characterized OGG1 (Demple and Harrison, 1994).
These ends must be converted to 5''-phosphate and 3''-hydroxyl termini in order to allow DNA polymerases and ligases to catalyze repair synthesis and strand rejoining.
 
 
 
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