The compound we identified forces the catastrophic failure of the normal virus amplification cycle and illustrates a new drug-accessible restriction point
for poxviruses in general," said John Connor, PhD, assistant professor of microbiology at BUSM.
The blood test measures the integrity of the cell cycle G1/S restriction point
in peripheral blood lymphocytes.
It is far easier to create a spot restriction in the sprue and carefully monitor pouring time to detect erosion of this restriction point
Cycle regulation was introduced, with the major proliferation control located at the restriction point
in late G1.
This is the first time that quantitative evidence has pointed to the necessary existence of a key metabolic factor controlling passage through the restriction point
in the cell cycle that commits the cell to DNA replication.