retinoid receptor


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retinoid receptor

[′ret·ən‚ȯid ri‚sep·tər]
(cell and molecular biology)
Any member of a family of nuclear receptors that mediate the actions of natural and synthetic analogs of vitamin A (retinoids) by regulating the transcription of retinoid-responsive genes in the cell nucleus.
References in periodicals archive ?
It is known that expression of the retinoid receptor RARbeta2 is lost as OSCC develops and we have compelling evidence that this is due to a novel role in replicative senescence, an in-built cell division limit, which functions as an anticancer system.
Pharmacological doses of some synthetic retinoids can modulate both the aryl hydrocarbon receptor and retinoid receptor pathways.
This is the first line of evidence for the presence of a retinoid receptor in this particular tissue being important in the pattern of organization being laid down during early regeneration," Hopkins says.
the industry's leading provider of cell-based nuclear receptor reporter assay products and services, has added all nine retinoid receptor assays to the company's significant suite of kits and screening services.
Alitretinoin is the only retinoid that is known to act on both types of retinoid receptor, and for this reason it is sometimes described as a (retinoid) panagonist.
The Allergan retinoid receptor research team that discovered TAZORAC(R) (tazarotene), currently one of the fastest growing acne products in the United States, will join Concurrent as part of the transaction.
Retinoid receptor binding sites have been identified in the promoter region for MMP-21 expression, thus retinoic acid upregulates MMP21 mRNA in monocytic U937 cells [1] and the enzyme has been found in cancer cells.
This may be attributable to tazarotene's retinoid receptor selectivity.
In APL about 90% of affected individuals have a reciprocal chromosome 15;17 translocation in which the t(15;17) breakpoint occurs near the retinoid receptor RAR [alpha] gene (Figure 1).
The second chapter of this volume is entitled: 'Animal models for retinoid receptor research: Implications for epidermal homeostasis, skin barrier function, wound healing, and atopic dermatitis', by N.
This normally all happens in a precisely timed and sequential way, but the initial step is the binding of ligand to the retinoid receptor.
The most significant finding in recent years, I think, is the discovery that the retinoid receptor called 'RXR', or the rexinoid receptor, which binds the derivative 9-cis-retinoic acid and has multiple functions acting in concert (as a heterodimer) with a whole range of other hormone-type receptors in the cell.
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