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reverse mutation

   Also found in: Dictionary/thesaurus, Medical, Legal, Wikipedia 0.01 sec.
reverse mutation [ri′vərs myü′tā·shən]
(genetics)
A mutation in a mutant allele which makes it capable of producing the nonmutant phenotype; may actually restore the original deoxyribonucleic acid sequence of the gene or produce a new one which has a similar effect. Also known as back mutation.


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The battery includes a test for gene mutation in bacteria (commonly the Ames bacterial reverse mutation test), IVC (in vitro cytogenetic) evaluation of chromosomal damage with mammalian cells or an in vitro (MLA) mouse lymphoma tk assay and an in vivo test for chromosomal damage using rodent haematopoietic cells (Figure 1).
Tests performed were acute oral toxicity, repeated dose 28-day oral toxicity, bacterial reverse mutation, in vitro chromosome aberration, micronucleus and dermal sensitization, as well as a 4-week immunotoxicity study.
Stanley Plotkin's thoughtful overview of the 11 disease-specific chapters annotates new vaccine technologies as well as current issues of debate, such as replacing the live oral polio vaccine worldwide with injectable, inactivated polio vaccine once the eradication program breaks the chain of wild-virus circulation, to avoid reverse mutations and resulting vaccine-associated paralysis.
 
 
 
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