reverse mutation


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reverse mutation

[ri′vərs myü′tā·shən]
(genetics)
A mutation in a mutant allele which makes it capable of producing the nonmutant phenotype; may actually restore the original deoxyribonucleic acid sequence of the gene or produce a new one which has a similar effect. Also known as back mutation.
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The basic assessment is a bacterial reverse mutation test, using a battery of different strains as well as metabolic activation.
As specialists in genotoxicity, Gentronix intends to initially offer GLP compliant Ames and in vitro micronucleus (MNT) tests as prescribed in the " OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects" tests 471: Bacterial Reverse Mutation and 487: In Vitro Mammalian Cell Micronucleus Test.
Ames Assay / Reverse mutation PASS - HAp coated stent is Salmonella of histidine and not mutagenic in the test Typhorium and tryptophan genes species.