reverse mutation


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reverse mutation

[ri′vərs myü′tā·shən]
(genetics)
A mutation in a mutant allele which makes it capable of producing the nonmutant phenotype; may actually restore the original deoxyribonucleic acid sequence of the gene or produce a new one which has a similar effect. Also known as back mutation.
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OECD Guideline for Testing of Chemicals, Bacterial Reverse Mutation Test.
Extraction medium TA 98 TA 100 TA 102 TA 1535 TA 1537 Water None None None None None Ethanol 40% (V/V) None None None None None Ethanol 70% (V/V) None None None None None Ethanol 96% (V/V) None None None None None Heptane None None None None None Table 6 Mutagenicity of root extracts from Valeriana officinalis L in the bacterial reverse mutation test (Ames-Test).