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rheumatoid arthritis |
Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia, Hutchinson | 0.09 sec. |
rheumatoid arthritisChronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course. It usually starts gradually, with pain and stiffness in one or more joints, then swelling and heat. Muscle pain may persist, worsen, or subside. Membrane inflammation and thickening scars joint structures and destroys cartilage. In severe cases, adhesions immobilize and deform the joints, and adjacent skin, bones, and muscles atrophy. If high-dose aspirin, ibuprofen, and other NSAIDs do not relieve pain and disability, low-dose corticosteroids may be tried. Physical medicine and rehabilitation with heat and then range-of-motion exercises reduce pain and swelling. Orthopedic appliances correct or prevent gross deformity and malfunction. Surgery can replace destroyed hip, knee, or finger joints with prostheses. There is also a juvenile form of the disease. |
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| In both the RAPID 1 (027) and RAPID 2 (050) studies CIMZIA(TM), in combination with methotrexate, demonstrated superiority to placebo, and a statistically significant improvement in the signs and symptoms of rheumatoid arthritis as measured by all American College of Rheumatology (ACR) scores: ACR20, 50, and 70. hereinafter "Roche") announced today that the humanized anti-human IL-6 (interleukin-6) receptor monoclonal antibody, Actemra(R) (generic name: tocilizumab (genetical recombination) injection), globally co-developed by Chugai and Roche, has shown efficacy as a monotherapy in rheumatoid arthritis patients in a double-blinded phase III trial conducted in Japan. Rheumatoid arthritis (RA) is a systemic inflammatory disease that produces a progressive degeneration of the musculoskeletal system. |
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