riboflavin


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riboflavin:

see coenzymecoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
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; vitaminvitamin,
group of organic substances that are required in the diet of humans and animals for normal growth, maintenance of life, and normal reproduction. Vitamins act as catalysts; very often either the vitamins themselves are coenzymes, or they form integral parts of coenzymes.
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.

Riboflavin

 

(also lactoflavin and Vitamin B2), an important and biologically active substance that is a derivative of the heterocyclic compound isoalloxazine attached to ribitol, a multi-atomic alcohol.

Riboflavin is widely distributed in the cells of microorganisms, plants, and animals, although animals are unable to bio-synthesize riboflavin and must obtain it with food. The biological role of riboflavin is determined by the presence of its derivatives—flavin mononucleotide (FMN) and flavin-adenine dinucleotide (FAD)—in a series of oxidation and reducing enzymes (flavoproteins) during electron transfer reactions and the metabolism of amino acids and other vitamins.

In man, many diseases are accompanied by disorders of the metabolism of riboflavin. A deficiency of riboflavin results in skin lesions and vision disorders, while an acute insufficiency leads to the development of a comatose state. Riboflavin is present in most food products, including brewer’s yeast, egg yolk, beef liver, and milk products. It is also synthesized by intestinal bacteria.

The structure of riboflavin was independently established in 1935 through chemical synthesis both by R. Kuhn and P. Karrer. Riboflavin is used in medicine as a vitamin preparation.

REFERENCE

Vitaminy. Moscow, 1974. Chapter 8.

riboflavin

[′rī·bə‚flā·vən]
(biochemistry)
C17H20N4O6 A water-soluble, yellow orange fluorescent pigment that is essential to human nutrition as a component of the coenzymes flavin mononucleotide and flavin adenine dinucleotide. Also known as lactoflavin; vitamin B2; vitamin G.

riboflavin

, riboflavine
a yellow water-soluble vitamin of the B complex that occurs in green vegetables, germinating seeds, and in milk, fish, egg yolk, liver, and kidney. It is essential for the carbohydrate metabolism of cells. It is used as a permitted food colour, yellow or orange-yellow (E101). Formula: C17H20N4O6
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A central 7 mm round corneal deepithelialization for efficient penetration of riboflavin through exposed corneal stroma was performed with the help of sterile blunt spatula.
Correlating rheological properties and printability of collagen bioinks: the effects of riboflavin photocrosslinking and pH," Biofabrication, Volume 9, Number 3, online 5 July 2017, DOI: 10.
Riboflavin is able to pass through the lipid cellular membrane and be incorporated into nucleic acid chains.
The riboflavin production was evaluated by the method described by Ashoor et al.
To date, there is no longitudinal study about the efficacy of glucocorticoids on late-onset MADD, not to mention the comparation of glucocorticoids and riboflavin on muscle strength and laboratory data during treatment.
Corneal collagen cross-linking with riboflavin and ultraviolet - A light for keratoconus: Results in Indian eyes.
Large-scale surveys conducted within the United States have reported noticeable riboflavin deficiencies among the elderly to be between 10% and 27% [1].
As noted above, riboflavin is a component of FAD, and it has been shown that individuals with the MTHFR 677TT genotype develop hyperhomocysteinemia only if they have poor riboflavin status.
Crispy and crammed full of flavour and Weetabix fuel, Weetabix Crispy Minis are made to fit perfectly onto the spoon, are high in fibre, made from 100% wholegrain, low in salt and are fortified with Niacin, Thiamin (B1), Riboflavin (B2), Folic Acid and Iron.
The interaction of riboflavin and UVA produces a reactive oxygen species, which causes the formation of additional covalent bonds between collagen molecules, consequently producing a biomechanical stiffening of the cornea.