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rifampin
(redirected from rifampicin)

   Also found in: Dictionary/thesaurus, Medical, Acronyms, Wikipedia 0.06 sec.
rifampin (rĭfăm`pĭn), antibiotic antibiotic, any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms.

Types of Antibiotics


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 used in the treatment of tuberculosis tuberculosis (TB), contagious, wasting disease caused by any of several mycobacteria. The most common form of the disease is tuberculosis of the lungs (pulmonary consumption, or phthisis), but the intestines, bones and joints, the skin, and the genitourinary,
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. It is also used to eliminate the meningococcus microorganism from carriers and to treat leprosy leprosy or Hansen's disease (hăn`sənz)
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, or Hansen's disease. Rifampin, or rifampicin as it was formerly called, acts by inhibiting protein synthesis in sensitive cells. It is a toxic drug whose side effects include flulike symptoms. Because resistant microorganisms emerge during treatment, rifampin is used along with other drugs, e.g., with isoniazid isoniazid (ī'sōnī`əzĭd), drug used to treat tuberculosis .
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 and ethambutol for tuberculosis treatment and with dapsone and clofazimine in the treatment of leprosy.

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All cefoxitine-resistant isolates underwent further identification and susceptibility testing to cefoxitine, gentamicin, vancomycin, teicoplanin, clindamycin, erythromycin, rifampicin, ciprofloxacin, cotrimoxazol, and tetracycline, using the Phoenix Automated Microbiology System (Becton Dickinson, Franklin Lakes, NJ, USA).
Leprosy is now typically cured with multiple drug therapy (some combination of rifampicin, clofazimine and dapsone) administered for six to 12 months, sometimes longer.
Rifampicin (RIF) and pregnenolone 16[alpha]-carbonitrile (PCN) were purchased from BioMol (Plymouth Meeting, PA).
 
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