scala tympani


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Related to scala tympani: Scala media, scala vestibuli, vestibular membrane

scala tympani

[′skā·lə tim′pan·ē]
(anatomy)
The lowest channel in the cochlea of the ear; filled with perilymph.
References in periodicals archive ?
The first safety question was, Could multiple electrodes be placed safely within the scala tympani of the cochlea [36-38] without significant damage to its delicate structures and especially the auditory nerve fibers?
My research on biological safety began in 1972 [45], and it demonstrated that when multiple electrodes were inserted into the scala tympani of the cochlea through a number of holes drilled in the overlying bone, marked damage of all structures and associated loss of the auditory nerve fibers were found (Figure 9) [45].
The second question was, What were the right mechanical properties required for an electrode bundle to pass upward far enough without trauma around the scala tympani and lie opposite the auditory nerves and transmit speech frequencies on a place coding basis?
The electrode carriers were found to pass only 10 to 15 mm upward into the tightening spiral of scala tympani of the basal turn.
studied the diffusion of radioiodine (NT-3) instilled into the scala tympani and found that 125I-labeled NT-3 reached all the turns of the cochlea after only 24 hours but the density of the signal varied for different structures in each turn of the cochlea [186].
Because the research just discussed showed the delivery of a nerve growth factor into the cochlea with a Micropump was inefficient, its localized release from a polymer in the scala tympani was a better option.
Research showed that factors such as trauma, infection, or just implantation would cause fibrous tissue and bone in the scala tympani and be associated with hair cell loss [188].
This strategy would provide a better overall timing control than the use of electrical stimulation together with a hearing aid, and for speech processing strategies of the future, this strategy is promising if the current can be focused along the scala tympani and be less influenced by pathology near the round window, as for a hearing aid.
Staecker et al reported (1) that direct infusion of either neurotrophin-3 or BDNF into the scala tympani of a guinea pig cochlea after a loss of auditory hair cells compensates for the loss of trophic support (i.