secondary amyloidosis


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Related to secondary amyloidosis: primary amyloidosis, AA amyloidosis

secondary amyloidosis

[′sek·ən‚der·ē ‚am·ə‚lȯi′dō·səs]
(medicine)
Amyloidosis that usually follows chronic suppurative, inflammatory diseases, such as tuberculosis, osteomyelitis, and bronchiectasis.
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Most patients progress to chronic renal failure, while histological regression and/or clinical remission has been observed in a few instances of secondary amyloidosis after adequate treatment of the predisposing disease.
1) FMF is characterized by recurrent attacks of fever that can be accompanied by self-limiting arthritis, pleuritis, peritonitis and the possible development of secondary amyloidosis.
Renal and cardiac disease are seen in both primary and secondary amyloidosis, and renal failure is the most common cause of death.
Neurochem has advanced three drug candidates to clinical trials: Alzhemed(TM) for Alzheimer's Disease, Fibrillex(TM) for Secondary Amyloidosis and Cerebril(TM) for Hemorrhagic Stroke due to CAA.
In secondary amyloidosis, a reduction in amyloid deposition may occur following successful treatment of the underlying disease.
In addition, a dramatic decrease in secondary amyloidosis, the most serious complication of FMF, has been reported in Turkey in recent years.
8] In several reports on MALT lymphoma, we found only a few cases of secondary amyloidosis, none of them involving the breast.
has submitted an application to the Clinical Trials Unit of the Medicines Control Agency in the United Kingdom for initiation of a pivotal Phase II/III clinical study for Fibrillex(TM), an anti-amyloid drug for the treatment of patients suffering from Secondary Amyloidosis.
Secondary amyloidosis occurs with a wide range of predisposing or co-existent pathology like chronic infection-tuberculosis, inflammatory condition--rheumatoid arthritis cystic fibrosis, bronchiectasis, and Crohn's disease, Chronic renal failure, Multiple myeloma (4,5).
It was reported that the proinflammatory cytokine TNF-a could be involved in the pathogenesis of secondary amyloidosis.
She was then was referred to nephrology department and secondary amyloidosis was detected in her left kidney after biopsy.