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selectin

   Also found in: Medical, Wikipedia 0.01 sec.
selectin [sə′lek·tən]
(cell and molecular biology)
Any of a family of carbohydrate-binding, calcium-dependent cell adhesion molecules that play an important role in leukocyte-endothelial binding.


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The technique involves filling the tiny lipid containers, or nanoscale capsules, with a molecular cargo and coating the capsules with adhesive proteins called selectins that specifically bind to target cells.
Swedish scientists from Lund University in Malmo found that fucoidan inhibits the adhesion molecules known as P and E selectins, appeared to improve symptoms of inflammatory bowel disease in mice, and points to the crucial role that this type of selectin-inhibition, may play in the treatment of the disease in humans.
By inhibiting selectin interactions, GMI-1070 may be able to decrease the enhanced cell adhesion that results in vaso-occlusive crisis.
 
 
 
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