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selection pressure |
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selection pressure [si′lek·shən ‚presh·ər] (evolution) Those factors that influence the direction of natural selection. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Hepatitis B viral mutants can emerge in patients as a result of selection pressure from either immune response or treatment options. The most likely explanation is the low genetic barrier to resistance produced by synergistic selection pressure from all 3 drugs for 2 point mutation, M184V and K65R. These modes of action put strong selection pressure on bacteria to generate resistance, which makes existing antibiotics ineffective. |
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