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plaque |
Also found in: Dictionary/thesaurus, Medical, Wikipedia, Hutchinson | 0.02 sec. |
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plaque 1. Pathol any small abnormal patch on or within the body, such as the typical lesion of psoriasis 2. short for dental plaque plaque [plak] (medicine) A patch, or an abnormal flat area on any internal or external body surface. A localized area of atherosclerosis. (virology) A clear area representing a colony of viruses on a plate culture formed by lysis of the host cell. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Today, he says, it's most likely that there are two primary causes of dementia: an Alzheimer's disease type "pathology," represented by the neurofibrillary tangles and senile plaques of the disease, and vascular dementia, resulting from significant changes in blood vessels in the brain. Clumps of large, sticky proteins forming senile plaques have been observed in the brains of people with Alzheimer disease ever since neurologist Alois Alzheimer first described the disorder nearly a century ago. In 1984, researchers discovered that these senile plaques consist of a central core of beta amyloid protein, surrounded by a cluster of abnormal nerve cells clogged with twisted fibers called neurofibrillary tangles. |
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