in high Eukaryotes are devided into zgroups:
Not unexpectedly, in light of nature's preoccupation with complementarity and contrariety, serpins
also perform diverse nonproteolytic functions, including hormone carriage proteins (thyroxine-binding globulin, cortisol-binding globulin), tumor suppressor genes (maspin), and storage (ovalbumin, in egg white).
Characterization and functional analysis of Serp3: a novel myxoma virus-encoded serpin
involved in virulence.
Maspin, a serpin
with tumor- suppressing activity in human mammary epithelial cells.
Patterns of haplotype diversity within the serpin
gene cluster at 14q32.
Maspin is one of the more recently discovered members of the serpin
5] Nonstandard abbreviations: A1AT, [alpha]-1-antitrypsin; SERPIN
, serine protease inhibitor; COPD, chronic obstructive pulmonary disease; IEF, isoelectric focusing; MS, mass spectrometry; LC-MS/MS, liquid chromatography-tandem MS; TFE, trifluoroethanol; IAA, iodoacetamide; TFA, trifluoroacetic acid; DTT, dithiothreitol; FCS, fetal calf serum; Z 3-16, Zwittergent detergent 3-16; DMF, dimethylformamide; LOQ, limit of quantitation; MRM, multiple reaction monitoring.
Their paper, entitled "Antiangiogenesis: A novel activity for the cleaved conformation of the serpin
antithrombin III," states results of Drs.
The grant entitled "A Novel Recombinant Serpin
for the Treatment of Stroke" will provide funds for the continued development of the company's most advanced serine protease inhibitor, LEX 032, for the treatment of reperfusion injury.
In contrast, other serpin
-serine protease interactions were not affected (PAI is a serpin
, a class of protease inhibitors that includes a1-antitrypsin, a2-antiplasmin and antithrombin III).
alpha1-Antitrypsin Portland, a bioengineered serpin
highly selective for furin: application as an antipathogenic agent.
Subsequently, more than 190 different mutations of the gene that encodes C1-INH, serpin
peptidase inhibitor, clade G (C1 inhibitor), member 1 (SERPINGI ), have been described (5).