Neuraminic Acid

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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
(biochemistry)
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.

Neuraminic Acid

 

5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

References in periodicals archive ?
Two projects on the metabolism of Sia focussed on sialidase and Neu5Ac hydroxylase.
San Diego, California) is a novel sialidase fusion protein that has shown in vitro efficacy against PIV in a cotton rat infection model as well as in lung transplant and HSCT recipients [8, 10-14].
Cure of bacterial vaginosis was defined as a normal Nugent score, a negative sialidase test, and no symptoms or signs at day 30.
Thymoquinone-induced Neu4 sialidase activates NFkappaB in macrophage cells and pro-inflammatory cytokines in vivo.
Lysosomal sialidase (neuroaminidase) cleans sialic acid residues located in the last part of gangliosides, oligosaccharides and glycoproteins.
23) Other enzymes like mannosidase, fucosidase, hexosaminidase and sialidase also is elevated that expose buried adhesion receptors on mucosal epithelium thus increasing the adhesion of Gram negative bacteria this foster increased adhesion and colonization by respiratory pathogens.
Deactivation of cholera toxin by a sialidase monosialosylganglioside.
Sialate aldolase is a sialidase localized in the cytosol of mammalian cells or secreted by bacteria into the medium.
The presentation was entitled "DAS181, a Sialidase, Decreases Airway Resistance by Modulating Muscarinic Receptor Signaling.
Washington, June 10 (ANI): In a study on rodents, scientists at the Johns Hopkins University School of Medicine have found that spinal cord treatment with an enzyme, sialidase, can improve nerve regrowth, motor recovery and nervous system function.
The f antigen is known to be resistant to enzymes and other chemicals including Ficin, papain, trypsin, pronase, sialidase, DTT.