Neuraminic Acid

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neuraminic acid

[¦nu̇r·ə¦min·ik ′as·əd]
(biochemistry)
C9H17NO8 An amino acid, the aldol condensation product of pyruvic acid and N-acetyl-D-mannosamine, regarded as the parent acid of a family of widely distributed acyl derivatives known as sialic acids.

Neuraminic Acid

 

5-amino-3, 5-deoxy-D-glycero-n-galac-to-2-nonulosonic acid, a natural compound occurring as N- and O-acyl derivatives (sialic acids) in all the organs and tissues of animals and in certain microorganisms. The acyl derivatives of neuraminic acid (the most common of which are N-acetyl and N-glycolyl neuraminic acids) are constituents of natural glycolipids and glycoproteins, where they are bonded to monosaccharide radicals. The neuraminic acid radical is split off from the glycolipid and glycoprotein molecules under the action of the specific enzyme neuraminidase or dilute acids, thereby substantially altering the physicochemical and biological properties of the molecules. Certain pathological conditions (cancer, tuberculosis, mental disorders) induce a marked increase in the neuraminic acid content of fluids and tissues in the human body. In glycolipid form, neuraminic acid takes part in the fixation of certain viruses and neurotoxins in animal organisms. The biosynthesis of neuraminic acid is effected in the presence of hexosa-mine derivatives and pyruvic acid.

References in periodicals archive ?
Sialidosis is an LSD caused by the deficiency of NEU1 (a-N-acetyl neuraminidase-1) (lysosomal sialidase, EC 3.
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.
Lysosomal sialidase functions only when it is bound to another enzyme named cathepsin (Protective Protein Cathepsin A: PPCA).
But in the new study, researchers showed remarkable improvement on treating injured rat spinal cords with sialidase.
Following completion of his PhD, Rich moved to Australia where he spent one year as an NSERC post-doctoral fellow in the laboratory of Mark von Itzstein, working on design and synthesis of new inhibitors of influenza virus sialidase.
The virus titre in the cultured medium was determined by measurement of influenza virus sialidase activity according to the procedure of Nagai et al.
2009) showed that OC significantly inhibits Streptococcus pneumoniae NanA sialidase as reflected in decreased biofilm formation, with an IC (50) (concentration necessary to inhibit enzyme activity by 50%) of 2 mM (568 mg/L) and an IC (30) of 28.
Treatment of secreted HMW proBNP with a mixture of O-linked deglycosylation enzymes (O-glycosidase, [beta]-galactosidase, glucosaminidase, peptidyl N-glycosidase F) and sialidase reduced the molecular weights of immunoreactive proBNP to 11-13-kDa species.
Yamamoto and colleagues treated purified Gc protein with immobilized [beta]-galactosidase and sialidase to make the Gc-MAF used in their studies.
The test detects elevated vaginal fluid sialidase, an enzyme produced by the bacterial pathogens associated specifically with bacterial vaginosis.
For better understanding of how carbohydrates are involved in rotavirus infection, he said, they had focussed on treating mammalian cells with a protein called sialidase.
There is no documented report of the accumulation of [alpha]-mannosidases in CHO-K1 or COS-7 cell supernatants, [alpha]-Fucosidase (21) and sialidase activity have been shown in CHO-K1 cells (22).