hemoglobin S

(redirected from sickle cell hemoglobin)
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hemoglobin S

[′hē·mə‚glō·bən ′es]
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Table 1: Hb: hemoglobin, HPLC: high performance liquid chromatography, HbS: sickle cell hemoglobin, HbF: fetal hemoglobin, HbA and HbA2: adult hemoglobin, and PTH: parathyroid hormone.
ACS occurs in children with sickling hemoglobin (HbS) presenting as classic sickle cell hemoglobin (HbSS); however, ACS may also occur in Sickle-thalassemia, and Sickle-hemoglobin C disease (HbSC).
Each test requires 2 ml of reconstituted solubility buffer and 20 [micro]l of anticoagulated whole blood or 20 [micro]l of sickle cell hemoglobin control.
Sickle Cell Hemoglobin (HbAS) indicates as sickle cell trait and Sickle cell disease (HbSS) indicates as sickle cell anemia with hemoglobin electrophoresis.
Sickle cell hemoglobin occurs as a result of thymine replacing adenine in the sixth codon of the beta-globin gene.
In one case series of 233 adult patients who were followed up after 9 years, the investigators found a 40% reduction in mortality with the drug, a cytotoxic agent that increases fetal hemoglobin and decreases sickle cell hemoglobin.
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