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Related to sickle-cell anemia: Tay-Sachs disease, hemophilia
sickle-cell anemia[′sik·əl ¦sel ə′nē·mē·ə]
A chronic, hereditary hemolytic and thrombotic disorder in which hypoxia causes the erythrocyte to assume a sickle shape; occurs in individuals homozygous for sickle-cell hemoglobin trait. Also known as sickle-cell disease.